血清胱蛋白酶抑制剂C对评价狼疮性肾炎患者肾小球病理损害程度的价值

Significance of Serum Cystatin C in Evaluating the Degree of Glomerular Pathological Damage in Patients with Lupus Nephritis

目的:探讨狼疮性肾炎患者血清胱蛋白酶抑制剂C(cystatin C)在评价肾小球病理损害程度中的价值。方法:选择狼疮性肾炎患者93例,入院后测定血清cystatin C,并行肾穿刺活检,对肾小球病理进行评分。分析cystatin C与肾小球病理评分的相关性,比较不同病理分级间cystatin C水平的差异。结果:血清cystatin C与狼疮性肾炎患者肾小球病理评分(r=0.7538,P=0.000)呈正相关,相关性具有统计学意义,肾小球病理1～3级间cystatin C水平的差异具有统计学意义(均P<0.01)。结论:血清cystatin C水平可以客观地评估狼疮性肾炎患者肾小球病理损害程度,是检测肾小球病理及功能改变的理想血清标志物。

Objective：To study the significance of serum cystatin C in evaluating the degree of glomerular pathological damage in patients with lupus nephritis.Methods：Serum cystatin C of 93 inpatients with lupus nephritis were measured by enzymed-linked immunosorbent assay,and tissue samples were harvested by percutaneous renal biopsies at the same time.The correlation between serum cystatin C and pathological scores of glomerulus,and the differences of serum cystatin C levels among the pathological classes for glomerulus were analyzed.Results：There was significance in correlation between serum cystatin C and pathological scores of glomerulus（r=0.753 8,P=0.000）.Serum cystatin C among different pathological grades for glomerulus had very statistically significant differences（P〈0.01）.Conclusion：Serum cystatin C can be used to evaluate objectively the degree of glomerular pathological damage,and might be an ideal serum marker for monitoring the impairment of glomerular pathology and function.