血清白细胞介素8水平在儿童支气管哮喘中的变化及意义

Changes and Clinical Significance of Serum Interleukine 8 in Children Bronchical Asthma

应用ELISA方法检测了28例小儿支气管哮喘发作时血清IL－8含量。结果发现支气管哮喘患儿血清IL－8含量为415．6±291．50pg／ml，明显高于正常对照组85．25±39．54pg／ml，而且重症患儿血清IL－8含量637．35±360．19pg／ml明显高于轻症患儿162．11±63．54pg／ml。当哮喘发作会并感染时，血清IL-8含量562．17±356．67pg／ml，高于不伴感染哮喘患儿183．5±116．58pg／ml。因此我们认为，儿童支气管哮喘时，IL－8合成释放增加，可能参与了哮喘的发病机制，血清IL－8的检测为判断病情，了解有无感染；提供了一个较好的实验参数。

The levels of serwe IL-8 were determined by enzyme linked immunosoubent assay(ELISA) in28 ckildren petients with bronchical asthma . The results showed that IL-8 levels of asthma (415. 6 ±291. 50ph/ml) were markedly higber than those of the normal controls (85. 25 ±39. 54 pg/ml). Wen theywere complicated witk iufections, the levels of IL-8 were higber than those in uncomplicated cases.In serious cases their serum levels of Il-8 (637. 35±360. 19pg/ml) were higher than those (162. 11±63. 54pg/ml) in mild ones. We know that the synothesis and release of IL-8 were increased when asth-ma occurred, which might be a factor involved in wechanism of children asthma. Assaying the levelsof IL-8 is helpful in analyzing the ckildren bronckical asthma cases,kether infected or not, seri-ous or mild.