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大鼠脑缺血-再灌注损伤后Nogo-A及IGF-1的表达和意义 被引量：4

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摘要 目的探讨大鼠脑缺血-再灌注(I-R)损伤后髓鞘相关蛋白(Nogo-A)和胰岛素样生长因子-I(IGF-1)的表达和意义。方法成年健康雄性Wistar大鼠72只,随机分为Nogo-A组和IGF-1组,每组各36只。应用线栓法制备大鼠大脑中动脉I-R动物模型,免疫组织化学方法检测Nogo-A与IGF-1在神经元凋亡中的表达。结果假手术组TUNEL凋亡神经细胞较少,脑I-R 2h海马区、皮质区及纹状体区细胞凋亡逐渐增加,7d细胞凋亡达高峰,14d降低。脑I-R 2h^14d,Nogo-A表达明显增加,皮质区和纹状体区再灌注12h和48h出现两个表达高峰,海马区再灌注24h出现一个高峰。脑I-R 2h^14d神经细胞IGF-1表达明显增加,24h达最高峰,14d仍维持高值水平。结论Nogo-A与IGF-1参与抑制并促进神经元轴突再生的表达。
作者 杜秀民 刘红 刘广义
机构地区 青岛大学医学院附属海慈医院神经内科 青岛市第九人民医院检验科 青岛大学医学院脑血管病研究所
出处 《中国老年学杂志》 CAS CSCD 北大核心 2008年第11期1061-1063,共3页 Chinese Journal of Gerontology
基金 青岛市科技局基金资助项目(05-1-NS-73)
关键词 脑缺血-再灌注 NOGO-A IGF-1 神经元 凋亡
分类号 R-332 [医药卫生] R338 [医药卫生—人体生理学]
  • 相关文献

参考文献9

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二级参考文献13

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中国老年学杂志
2008年 第11期

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