采用AS—OCT测量房角开放度数的一致性分析

Reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography

目的探讨采用眼前段光学相干断层扫描仪（AS—OCT）定量测量房角，并分析其测量一致性。方法采用AS—OCT对23例受试者（30只眼）的房角进行扫描，分别由测量者甲和乙，以及测量者甲在两个不同的时间点对颞侧房角500μm（AA-500μm）和750μm（AA-750μm）的房角开放度数进行定量测量。采用类内相关系数ICC和95％LoA（95％Limts of Agreement，95％LoA）评价测量的一致性。结果甲两次测量的AA-500μm和AA-750μm值比较差异均无统计学意义（均P〉0．05）；甲与乙测量的AA-500μm和AA-750μm值比较差异均无统计学意义（均P〉0．05）。AA-500μm和AA-750μm测量者内的95％LoA分别为（-5．441，5．281弧度和-7．313、6．020弧度）；ICC分别为：0．933，0．907。AA-500μm和AA-750μm测量者间的95％LoA分别为：（-6．098，5．098弧度和-7．877、5．423弧度）；ICC分别为0．925，0．887。结论AS—OCT测量房角开放度数的一致性较好，可以用于定量测量房角开放度数。

Objective To assess reproducibility of anterior segment optical coherencetomograpby （AS-OCT） to quantify the anterior chamber angle （AA）. Methods 23 eyes of 30 subjects were enrolled. Anterior champer angle was scanned using AS-OCT, and the 500 μm （AA-500 μm） and 750 μm （AA-750 μm） temporal anterior cbampcr angle were measured by two ophthalmologists, respectively. And one observer repeatedly measured its in two different times. Analyzing the reproducibility with intraclass correlation coefficient （ICC） and 95% Limts of Agreement （95%LoA）. Results The difference in AA-500 μm and AA-750 μm measurements between two observers were not significant （all P 〉0.05）, and its were also no significant difference between the first and the second measurement for same observer （all P 〉0.05）. The 95% LoA of intraobserver of AA-500μm and AA-750 μm were -5.441 to 5.281 degrees and -7.313 to 6.020 degrees, respectively. The ICC of intraobscrvcr ofAA-500 μm and AA-750μm were 0.933 and 0.907, respectively. The 95% LoA ofintcrobserver of AA-500μm and AA-750μm were -6.098 to 5.098 degrees and -7.877 to 5.423 degrees, respectively. The ICC of interobserver of AA-500 μm and AA-750 μm were 0.925 and 0.887, respectively. Conclusions This study demonstrated that the AS-OCT measurements for AA showed a high degree of reproducibility. Thus, AS-OCT can be used to quantitative measurement AA in the clinic.