法洛四联症左心功能的MRI研究

Study left ventricular function of tetralogy of Fallot by MRI

目的研究MRI心功能测定技术评价法洛四联症(TOF)患者左心功能的临床应用价值。方法用MRI测量30例TOF患者手术前后的左室舒张末期容积(LVEDV)、射血分数(LVEF)和心输出量(LVCO),结果与正常对照组进行比较,分析MRI与超声心动图(ECG)测量结果的相关性。结果TOF组LVEDV低于正常对照组(P<0.05);LVEF高于正常对照组(P<0.05)。MRI测量的LVEF、LVEDV与ECG具有良好的相关性(rLVEDV=0.52,P<0.05;rLVEF=0.54,P<0.05)。TOF根治术后LVEDV,LVCO较术前明显增大。结论MRI心功能测定技术可作为评价法洛四联症手术前后心室功能改变的可靠方法,对评估TOF患者手术预后有重要的临床意义。

Objective To study the clinical value of magnetic resonance imaging（MRI）in evaluating left ventricular function of patients with Tetralogy of Fallot（TOF）.Methods Thirty patients with tetralogy of Fallot were underwent MRI,left ventricular end dilated volume（LVEDV）,left ventricular ejection fraction（LVEF）and cardiac output（LVCO）were obtained.The results were compared with normal control group,and the relationship with echocardiography（ECG）were analysed with linear relation and regression analysis.Results The LVEDV in TOF group was significantly less than normal control group（P〈0.05）while the LVEF was significantly higher than normal control group（P〈0.05）.The LVEF and LVEDV measured by MRI had significantly positive relationship with ECG（rLVEDV=0.52,P〈0.05,rLVEF=0.54,P〈0.05）.The LVEDV and LVCO were significantly increased after operation（P〈0.1）.Conclusion MRI is a reliable technique for assessing heart function of tetralogy of Fallot before and after operation which plays an important role in post operation medical management.