1-萘酚的β-取代金属卟啉的合成及其抗菌活性

Synthesis and antibacterial activity of β-substituted metal porphyrins of 1-naphthol

为了研究新型光敏剂,利用1-萘酚和2-硝基-5,10,15,20-四苯基金属卟啉反应,合成了2-(1-羟基萘基)-5,10,15,20-四苯基金属卟啉,产率达70%以上,并对其结构进行表征.研究了2-(1-羟基萘基)-5,10,15,20-四苯基铜卟啉和镍卟啉对金黄色葡萄球菌(Staphylococcus aureus ATCC 25923)的抑菌活性,发现2-(1-羟基萘基)-5,10,15,20-四苯基镍卟啉具有一定的光敏抑菌活性.

To study novel photosensitizers, 2-（1-hydroxynaphthyl）-5, 10, 15,20 tetraphenylpo - rphyrinato metal compounds have been synthesized by rbaction of 2-nitro-5, 10, 15, 20- tetraphenylporphyrinato metal comiaounds with 1-naphthol in higher than 70% yields and their structures were characterized. The bactericidal activity on Staphylococcus aureus ATCC 25923 has been tested with 2-（1-hydroxynaphthyl）-5,10,15,20-tetraphenylporphyrinato metal compounds. It is shown that the Ni（ Ⅱ ） complexes has photodynamic antibacterial activity.