重组人生长激素的主要药效学研究

Effect of Recombinant Human Growth Hormone on Plateaued Rat Grouth

参照文献方法［１－４］，观察了ｒｈＧＨ对正常大鼠（３月龄，平台期）生长发育作用的影响，ｉｍ，ｒｈＧＨ（００５、０１５、０４５ｍｇ·ｋｇ－１·ｄ－１），连续１５天，结果表明：ｒｈＧＨ（０１５、０４５ｍｇ·ｋｇ－１·ｄ－１）同阳性对照药（人生长激素ＮＩＢＳＣ标准品）一样，均可明显促进正常平台期大鼠的体重及尾长增加，大剂量组还可明显促进肝、肾及骨骼的生长发育，使肝、肾重量增加，胫骨骨骺端距离增大，同时还可增加血清磷含量及降低尿液中尿素氮（ＢＵＮ）的排泄。

A kind of E.coliderived Recombinant Human Growth Hormone (rhGH) was administered as daily muscular injection to plateaued rats for 15 days in 0.05,0.15 and 0.45mg/kg·d respectively,growth response of rat to rhGH had been studied.Compared with positve controlled drug (rhGH from NIBSC),the tested rhGH could significantly increase body weight and tail length of rat. 0.45mg/kg·d administration could also remarkably improve development of liver,kidney and skeleton,enhance Pi content in serum,decrease BUN level in urea.Research result showed that tested rhGH has significant effect on growth of rat.*