摘要
作者观察了120例腹腔镜胆囊切除术患者手术前后免疫功能的变化。结果发现手术后IgG、IgM水平以及CD3+、CD4+、CD8+均显著高于手术前及气腹后(P<0.01)。补体C3及C4水平在手术后显著高于手术前(P<0.05及P<0.01),而CIC及CH50水平则显著低于手术前(P<0,05及P<0.01)。这些观察结果说明腹腔镜胆囊切除术后机体细胞免疫及体液免疫功能增强,肝脏C3及C4产生增加,而对CIC的清除增加。这些变化可能是机体对高压CO2气腹及高碳酸血症的应激反应。
In this study,changes in immunity were observed in 120 patients undergoing laparoscopiccholecystectomy. It was found that postoperative levels of IgG,IgM,CD3+,CD4+,and CD8+ were significantly higher than that of preoperative and postpneumoperitoneal with CO2 (P<0.01 ). Postoperativecomplement levels of C3 and C4 were significantly higher than that of preoperative (P<0. 05 and P<0.01 respectively),whereas the postoperative levels of,CIC and CH50 remarkably decreased compared withthat of preoperative(p<0. 05 and P<0. 01 respectively). Our results suggest that immune function increased in patients receiving laparoscopic cholecystectomy, hepatic production of C3 and C4 and clearanceof CIC was enhanced a probable response to high pressure of CO2 pneumoperitoneum and hypercarbia.
出处
《中华普通外科杂志》
CSCD
1997年第5期276-277,共2页
Chinese Journal of General Surgery
关键词
胆囊切除
腹腔镜
免疫测定
补体
Cholecystectomy,Laparoscopic,Immunoassay,Pneumoperitoneum,artificial