2型糖尿病患者血清esRAGE水平及相关因素研究

Study on the Serum Level of esRAGE and Other Related Factors in Patients with Type 2 Diabetes

目的研究2型糖尿病(T2DM)患者血清内源性分泌型糖基化终产物受体(esRAGE)水平及其与相关因素的关系。方法用酶联免疫法测定60例T2DM患者(其中30例并发颈动脉粥样硬化)和28名正常对照者血清es-RAGE浓度,并检测其他临床指标。结果T2DM并发颈动脉粥样硬化组血清esRAGE浓度较无颈动脉粥样硬化组及正常对照组显著降低,差异有高度统计学意义(P<0.01);T2DM无颈动脉粥样硬化组较正常对照组亦显著降低,差异有统计学意义(P<0.05)。Pearson相关分析显示,esRAGE与年龄及代谢综合征的组成因素包括糖化血红蛋白、总胆固醇、低密度脂蛋白、收缩压、体质量指数成负相关(P<0.01)。多元线性逐步回归分析显示,年龄、总胆固醇、糖化血红蛋白、体质量指数与esRAGE成独立负相关(P<0.05)。结论esRAGE可能是糖尿病动脉粥样硬化及代谢综合征的潜在保护因素。

Objective To study the serum level of endogenous secretory receptor for advanced glycation end products （esRAGE） in type 2 diabetes （T2DM） and its relationship with other related factors. Methods Enzyme-linked immunosorbent assay （ELISA） was used to detect the serum esRAGE level in 60 T2DM 30 of which had carotid atherosclerosis and 28 normal controls,other clinical index was also tested. Results Serum esRAGE level was significantly lower in T2DM with carotid atherosclerosis than in T2DM without carotid atherosclerosis and in the normal controls（P〈0.01）. T2DM without carotid atherosclerosis was also significantly lower than that in the normal controls（P〈0.05）.Pearson correlation analysis showed serum esRAGE was inversely correlated with age and components of the metabolic syndrome including glycosylated hemoglobin Ale, total cholesterol, low density lipoprotein, systolic blood pressure and body mass index （P〈0.01）. Multiple linear regression analyses showed that age,total cholesterol, glycosylated hemoglobin Ale and body index were independently associated with esRAGE （P〈0.05）. Conclusion esRAGE is probably a potential protective factor for diabetes with atherosclerosis and metabolic syndrome.