ANCA相关性小血管炎并急进型肾炎Ⅲ型临床分析

Clinical analysis of ANCA-associated small vessel.

目的探讨抗中性粒细胞胞浆抗体(ANCA)相关性小血管炎并急进型肾炎(RPGN)Ⅲ型的临床,病理特点及诊治方法。方法对8例确诊为ANCA相关性小血管炎并RPGN患者临床资料进行总结分析。结果ANCA相关性小血管炎并RPGN临床表现多样,全身各系统均可受累,以肺、肾受累为主。一旦肾脏受累,常表现为RPGN,经皮质激素,细胞毒药物等治疗,部分患者肾功能得到改善,脱离透析治疗。结论ANCA相关性小血管炎并RPGN临床表现缺乏特异性,早期诊断,早期适当治疗可改善患者预后。

Objective To study the clinical significant, pathological feature, diagnosis and treatment of Antineutrophil cytoplasimic antibody （ ANCA）-associated small- vessel vasoulitis complicating rapid progressive glomerulonephritis （ RPGN ） Ⅲ. Methods To summarize and analysise the clinical documents of the defined patients with ANCA-associated small-vessel vasculitis complicating RPGN Ⅲ.Results The disease has varied clinical significant, and involves every system of the body, especially lung and kidney. Once it involves the kindney, the clinical significant is PPGN Ⅲ. Through the treatment of corticostcrolds, cytotoxic drug and others, the renal function of some patients has been improved. Conclusion The clinical siganificant of ANCA-asocciated small-vessel vasculitis copmliating RPGN Ⅲ is lack of the specificity. Eearly diagnosis and proper teaetment may improve the prognosis of the patient.