摘要
目的观察舒芬太尼预处理减轻1%丙泊酚注射痛的效果。方法择期全麻下腹腔镜胆囊切除术患者150例,随机分为舒芬太尼组(S,n=50),利多卡因组(L,n=50)和生理盐水组(C,n=50)。S组静脉推注10μg舒芬太尼1min后,注射丙泊酚5ml;L组静脉推注等量生理盐水后,注射丙泊酚与利多卡因混合液;C组静脉推注生理盐水后,注射丙泊酚5ml。在推注丙泊酚过程中用视觉模拟评分法(VAS)评估患者肢体的疼痛程度并记录患者上肢退缩的发生情况。结果S、L组患者VAS评分明显低于C组(P<0.01),而VAS评分在S、L组之间比较无统计学意义(P>0.05)。S、L组患者上肢退缩的发生率明显低于C组(P<0.05),而上肢退缩的发生率在S组、L组之间比较无统计学意义(P>0.05)。结论舒芬太尼预处理可以有效地减轻丙泊酚注射痛,其效果与利多卡因混合丙泊酚注射相当。
Objective To compare the efficacy of sulfentanil, lidocaine, and saline in minimizing the propofol injection pain,Methods 150 ASA Ⅰ - Ⅱ adult patients ndergoing elective laparoscopic cholecystectomy under general anesthesia were randomly divided into one of three groups:sulfentanil (Group S, n = 501, lidocaine( Group L, n = 501, saline (Group C, n = 501 . Patients in Group S received 10μg sulfentanil prior to administration 5 ml of propofol over 10s .40mg lidocaine + 20ml propofol, then patients in Group L was given 5 ml. Patients in Group C received 5 ml of propofol only .Pain was evaluated by use of a 10-point verbal analogue scale .The incidences of withdrawal movements of the arm were recorded. Results There were no significant differences in term of patient characteristics data. Group S and Group L were to found have lower propofol injection pain scores than Group C( P 〈 0.01 ), but there was no significant difference between Group S and L. The incidences of withdrawal movements of the arm in Group C was higher than those of Group S and L.Conclusion Sulfentanil 10ug Pretreatment can provide the same analgesic effect as that of lidocaine. Sulfentanil Pretreatment may be an alternative drug for prevention of propofol injection pain.
出处
《四川医学》
CAS
2008年第6期730-731,共2页
Sichuan Medical Journal