舒芬太尼预处理对丙泊酚注射痛的影响

The Effect of sulfentanil Pretreatment on Propofol Injection Pain.

目的观察舒芬太尼预处理减轻1%丙泊酚注射痛的效果。方法择期全麻下腹腔镜胆囊切除术患者150例,随机分为舒芬太尼组(S,n=50),利多卡因组(L,n=50)和生理盐水组(C,n=50)。S组静脉推注10μg舒芬太尼1min后,注射丙泊酚5ml;L组静脉推注等量生理盐水后,注射丙泊酚与利多卡因混合液;C组静脉推注生理盐水后,注射丙泊酚5ml。在推注丙泊酚过程中用视觉模拟评分法(VAS)评估患者肢体的疼痛程度并记录患者上肢退缩的发生情况。结果S、L组患者VAS评分明显低于C组(P<0.01),而VAS评分在S、L组之间比较无统计学意义(P>0.05)。S、L组患者上肢退缩的发生率明显低于C组(P<0.05),而上肢退缩的发生率在S组、L组之间比较无统计学意义(P>0.05)。结论舒芬太尼预处理可以有效地减轻丙泊酚注射痛,其效果与利多卡因混合丙泊酚注射相当。

Objective To compare the efficacy of sulfentanil, lidocaine, and saline in minimizing the propofol injection pain,Methods 150 ASA Ⅰ - Ⅱ adult patients ndergoing elective laparoscopic cholecystectomy under general anesthesia were randomly divided into one of three groups：sulfentanil （Group S, n = 501, lidocaine（ Group L, n = 501, saline （Group C, n = 501 . Patients in Group S received 10μg sulfentanil prior to administration 5 ml of propofol over 10s .40mg lidocaine ＋ 20ml propofol, then patients in Group L was given 5 ml. Patients in Group C received 5 ml of propofol only .Pain was evaluated by use of a 10-point verbal analogue scale .The incidences of withdrawal movements of the arm were recorded. Results There were no significant differences in term of patient characteristics data. Group S and Group L were to found have lower propofol injection pain scores than Group C（ P 〈 0.01 ）, but there was no significant difference between Group S and L. The incidences of withdrawal movements of the arm in Group C was higher than those of Group S and L.Conclusion Sulfentanil 10ug Pretreatment can provide the same analgesic effect as that of lidocaine. Sulfentanil Pretreatment may be an alternative drug for prevention of propofol injection pain.