摘要
本文总结了食管静脉曲线破裂出血195例,用奥曲肽(善得定,Sandostatin)治疗95例,垂体后叶素治疗100例。结果显示:奥曲肽组止血率为68.42%,明显优于垂体后叶素组(52%)(P<0.05),再出血发生率分别为17.89%和37%,急诊手术率分别为24.21%和30%,死亡率为7.36%和18%,副作用的发生率为8.42%和43%,表明奥曲肽是治疗食管静脉曲张破裂出血的有效药物。尤其对肝功能差、年老体弱、有重要脏器疾患、出血量大、手术高危的病人,能降低急诊手术率和死亡率。
Compared with octreotide and pituitrin,95 patients with esophageal varicose bleeding were treated with octreotide,and 100 patients with pituitrin.The results showed that octreotide arrested varicose bleeding in 68.42% patients,higher than pituitrin did in 52% ( P < 0.01 ),the re bleeding rate in the patients with octreotide was 17.89% ,much lower than that of pituitrin;mortality and surgery rate were 7.36% and 24.21% ,much lower than that of pituitrin ( P < 0.01 ),and octreotide produced complications in 8.42% ,much lower than that of pituitrin ( P < 0.01 ).We conclude that octreotide is an effective drug in the treatment of patients with esophageal varicose bleeding.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1997年第9期397-398,共2页
Chinese Journal of Hospital Pharmacy