奥曲肽和垂体后叶素治疗静脉曲张破裂出血的应用对比

Compared study with octreotide and pituitrin in the treatment of patients with esophageal varicose bleeding

本文总结了食管静脉曲线破裂出血１９５例，用奥曲肽（善得定，Ｓａｎｄｏｓｔａｔｉｎ）治疗９５例，垂体后叶素治疗１００例。结果显示：奥曲肽组止血率为６８．４２％，明显优于垂体后叶素组（５２％）（Ｐ＜０．０５），再出血发生率分别为１７．８９％和３７％，急诊手术率分别为２４．２１％和３０％，死亡率为７．３６％和１８％，副作用的发生率为８．４２％和４３％，表明奥曲肽是治疗食管静脉曲张破裂出血的有效药物。尤其对肝功能差、年老体弱、有重要脏器疾患、出血量大、手术高危的病人，能降低急诊手术率和死亡率。

Compared with octreotide and pituitrin,95 patients with esophageal varicose bleeding were treated with octreotide,and 100 patients with pituitrin.The results showed that octreotide arrested varicose bleeding in 68.42% patients,higher than pituitrin did in 52% ( P < 0.01 ),the re bleeding rate in the patients with octreotide was 17.89% ,much lower than that of pituitrin;mortality and surgery rate were 7.36% and 24.21% ,much lower than that of pituitrin ( P < 0.01 ),and octreotide produced complications in 8.42% ,much lower than that of pituitrin ( P < 0.01 ).We conclude that octreotide is an effective drug in the treatment of patients with esophageal varicose bleeding.