肺鳞癌间质内微血管的定量研究

Microvessel quantitation in squamous cell carcinoma of lung

目的：探讨肺鳞癌间质内微血管与肺癌临床病理的关系；方法：应用ＦⅧ相关抗体，并采用ＬＳＡＢ法对８９例手术切除的肺鳞癌微血管进行定量检测；结果：有淋巴结转移组肺鳞癌微血管密度每２００倍视野５０．２±２２．８个，无转移组为３４±１９．１个；有淋巴结转移组微血管腔面积为６９６１．８±２８６８．９平方象素，无转移组为４０３７．４±２４２５．３平方象素，两者在两组间比较，差异均有极显著性意义（ｔ＝３．１７，ｔ＝３．５８，Ｐ均＜０．０１）；微血管密度及腔面积在３组不同生存期的患者间差异亦均具有极显著性意义（Ｆ＝６．６２，Ｆ＝８．６５，Ｐ均＜０．０１）；结论：肺鳞癌间质内微血管生成与淋巴结转移和患者的预后有关。

Purpose To study the relationship between the microvessel quantitation and the clinical pathology of lung carcinoma. Methods Microvessel quantitation in 89 cases of lung squamous cell carcinoma was done with factor Ⅷ related antibody and LSAB method.Results In lymph node metastasis positive carcinoma, the microvessel count was significantly higher than that in node negative carcinoma ( t=3 17,P<0 01 ), and the area of microvessel lumen in node positive group was obviously higher than that in node negative group ( t=3 58, P<0 01 ). The microvessel count and the area of microvessel lumen were both obviously different among the three groups with various living time ( P<0 01, P<0 01 ). Conclusions The angiogenesis of lung squamous cell carcinoma is correlated with the lymph node metastasis and prognosis.