天津地区戊型肝炎流行及发病特征的研究

A Study on the Epidemiology and Clinical Characteristics of Hepatitis E in Tianjin Area

应用ELISA方法对192例戊型肝炎(HE)住院患者血清学、临床特征进行研究,探讨天津地区HE流行和发病特点。结果HE占病毒性肝炎的20%,中年男性居多;肠道内感染占78.6%;5例有近期输血史,占2.6%;临床表现类似甲型肝炎(HA),但不少方面有别于HA:HE只表现转氨酶(ALT)及胆红质(BIL)升高,未发现有慢性过程;重叠感染时ALT及BIL均低于单纯HE(P<0.01)。为此提出,天津地区HE为散发流行,肠道内感染为主,中年男性居多;HE存在血源传播的可能,指出对献血员做HEV筛选十分必要。同时提出HEV与其他病毒间存在相抑制作用。

Using ELISA to analyse 192 patients with hepatitis E(HE) on their clinical and epidemiologyic characteristics, in Tianjin Area. Results showed that 20 percent of the total patients diagnosed as viral hepatitis diseases belonged to HE. The majority of HE patients was middle-aged male with. 78.6 percent of them infected through alimentary canal. Five of them (2.6%) had a history of recent blood transfusion. The clinical picture of HE was similar to HA, showing only the increase of ALT and Bil, hut no chronic process. The levels of ALT and Bil in super-infection were lower than those seen in simple HE (P<0.01). Data showed that Hepatitis E in Tianjin Area was sporadic and the virus might be transmitted through blood transfusion. Blood screening program for HE virus was discussed. The author advanced the idea that HEV and other virus might restrain from each other.