摘要
消除各种内外源性致癌物对机体细胞和组织的侵害,是对癌症进行化学预防的有效方法,该过程与Ⅱ相代谢酶的作用有关,并主要受Nrf2/ARE通路调控。研究表明,某些天然化合物能通过Nrf2/ARE途径,诱导Ⅱ相代谢酶而发挥化学防癌作用。本文综述经上述途径发挥化学防癌作用的各种天然化合物。
Protecting cells or tissues from damage by many exogenous or endogenous carcinogens is the effective way for cancer chemoprevention. This protection could be achieved by the induction of phase Ⅱ metabolic enzymes which were mediated mainly by nuclear factor E2-related factor 2/antioxidant responsive element (Nrf2/ARE) pathway. It is suggested that some natural compounds, which exist chemopreventive effects, can activate Nrf2/ARE to mediate expression of phase Ⅱ metabolic enzymes, This review is focused on natural compounds as potential cancer preventive agents via the pathway mentioned above.
出处
《药学服务与研究》
CAS
CSCD
2008年第3期193-196,共4页
Pharmaceutical Care and Research
关键词
细胞转录因子/抗氧化反应元件
肿瘤
天然化合物
化学预防
Ⅱ相代谢酶
综述
nuclear factor E2 related factor 2/antioxidant responsive element (Nrf2/ARE)
neoplasms
natural compounds
cbemoprevention
phase Ⅱ metabolic enzymes
review