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经Nrf2/ARE通路发挥化学防癌作用的天然化合物 被引量：2

Natural compounds existing cancer chemopreventive effect via nuclear factor E2-related factor 2/antioxidant responsive element(Nrf2/ARE) pathway
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摘要 消除各种内外源性致癌物对机体细胞和组织的侵害,是对癌症进行化学预防的有效方法,该过程与Ⅱ相代谢酶的作用有关,并主要受Nrf2/ARE通路调控。研究表明,某些天然化合物能通过Nrf2/ARE途径,诱导Ⅱ相代谢酶而发挥化学防癌作用。本文综述经上述途径发挥化学防癌作用的各种天然化合物。 Protecting cells or tissues from damage by many exogenous or endogenous carcinogens is the effective way for cancer chemoprevention. This protection could be achieved by the induction of phase Ⅱ metabolic enzymes which were mediated mainly by nuclear factor E2-related factor 2/antioxidant responsive element （Nrf2/ARE） pathway. It is suggested that some natural compounds, which exist chemopreventive effects, can activate Nrf2/ARE to mediate expression of phase Ⅱ metabolic enzymes, This review is focused on natural compounds as potential cancer preventive agents via the pathway mentioned above.
作者 于宏 庄庆祺
机构地区 如新(中国)日用保健品有限公司
出处 《药学服务与研究》 CAS CSCD 2008年第3期193-196,共4页 Pharmaceutical Care and Research
关键词 细胞转录因子/抗氧化反应元件 肿瘤 天然化合物 化学预防 Ⅱ相代谢酶 综述 nuclear factor E2 related factor 2/antioxidant responsive element （Nrf2/ARE） neoplasms natural compounds cbemoprevention phase Ⅱ metabolic enzymes review
分类号 R286.91 [医药卫生—中药学] R345 [医药卫生—基础医学]
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参考文献27

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共引文献18

同被引文献41

  • 1钟敏.Nrf2-Keap1抗氧化系统研究进展[J].中国公共卫生,2006,22(3):360-362. 被引量：22
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  • 3叶社房,侯振清,钟李明,张其清.Nrf2/ARE在化学防癌机制中的作用[J].中华肿瘤防治杂志,2007,14(3):222-225. 被引量：8
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药学服务与研究
2008年 第3期

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