128株白色念珠菌感染菌种的分布及耐药分析

Distribution and Resistance Analysis of 128 Strains of Candida Albicans

目的了解院内白色念珠菌感染菌种的分布及耐药情况,为临床抗真菌治疗提供依据。方法采用VITEK微生物鉴定仪、酵母菌鉴定卡进行菌种鉴定,ATB FUNGUS 2真菌药敏条进行药敏试验。结果2006年6月～2007年6月从临床送检的痰、尿、分泌物等标本中共检出白色念珠菌128株,检出率为2.0%,其中痰标本白色念珠菌检出率最高93株占72.7%;在各年龄段白色念珠菌的分布中,70岁以上患者所占比例最大66.5%;同时以呼吸内科检出率最高36株占28.1%;体外药敏试验显示两性霉素B敏感性最好,耐药率最低为0。结论白色念珠菌感染越来越多,加强真菌分离及药敏监测,合理用药,有助于患者的治疗。

Objeetive To understand the distributioth and resista.nce of infected Candida albicans in our hospital, and to provide a basis for antifungal clinical treatment. Methods VITEK bacterial instruments and YBC card were used for the identification, and antifungal agents susceptibility was tested by ATB FUNGUS 2. Results One hundred and twenty eight strains of candida albicans were detected from the clinical submitted specimens of sputum, urine and secreta from June 2006 to June 2007 with the detection rate of 2.0%. The highest detection rate of the candida albicans in sputum specimens was 72.7 % （93 strains）. In the age distribution of the patients with candida albicans infection,patients over 70 years old had the largest share of 66.5% ,and from the respiration department the largest number of 36 （28. 1%）was solated. In in vitro drug sensitivity test, amphotericin B showed the best sensitivity, with the lowest resistance rate of 0. Conclusion Because of more and more candida albicans infections, separation.of fungus,susceptibility testing and rational drug use should be strengthened.