复方氨苯蝶啶的急性毒性及其保钾作用

Acute toxicity and potassium-sparing effect of Compound Triamterene

目的:考察复方氨苯蝶啶的安全性及其保钾作用。方法:将NIH小鼠及SD大鼠分别用6%氨苯蝶啶、30%氢氯噻嗪和复方氨苯蝶啶混悬液灌胃,观察氨苯蝶啶、氢氯噻嗪及复方氨苯蝶啶的急性毒性及对尿钾的影响。结果:与氨苯蝶啶、氢氯噻嗪的急性毒性相比,复方氨苯蝶啶的急性毒性较低。氢氯噻嗪组排尿量和排钾量与对照组比较显著升高(P<0.01),氨苯蝶啶组排尿量增加不明显,但明显减少排钾(P<0.01);复方氨苯蝶啶组明显增加排尿量(P<0.01),排钾量略减少。结论:复方氨苯蝶啶的安全性好,氨苯蝶啶与氢氯噻嗪合用可增加利尿效应并预防低钾血症。

Objective：To investigate the safety and the potassium-sparing effect of Compound Triamterene. Methods：NIH mice and SD rats were given 6% Triamterene, 30% Hydrochlorothiazide and Compound Triamterene by mouth.Acute toxicity and potassium-sparing effects of Triamterene, Hydrochlorothiazide and Compound Triamterene were observed.Results：The acute toxicity of Compound Triamterene was lower than that of Triamterene or Hydrochlorothiazide.The urinary excretion and potassium excretion in Hydrochlorothiazide group were markedly higher than that of control group（P〈0.01）. The increase of urinary excretion in Triamterene group was not evident,whereas potassium excretion reduced evidently （P〈 0.01）.The increasement of urinary excretion in Compound Triamterene group was evident （P〈0.01）,and potassium excretion reduced a little.Conclusion： The safety of Compound Triamterene is good. When Triamterene used with Hydrochlorothiaxide, the diuretic effect will be increased and the hypodalemia will be prevented.