三乙膦酸铝的纯化与离子色谱分析

The Purification of Fosetyl-Al and Its Quantitative Analysis by Ion Chromatography

采用二级水三次水洗抽滤的方法对三乙膦酸铝原药进行纯化。对制备的纯品采用碘量法、离子色谱法测定，质量分数均大于99．0％，能够满足离子色谱分析对标样的要求。同时采用AS 14、AS 9离子色谱柱明确了常见阴离子、淋洗液浓度对三乙膦酸铝分离的影响，最后采用Na2CO3溶液为淋洗液，AS 9离子色谱柱，电导检测器建立了三乙膦酸铝的离子色谱定量方法，并对该方法进行了评价。结果表明，常量分析方法的准确度（添加回收率99．6％～101．0％）和精密度（RSD 0．31％）均较好。

The fosetyl-Al whose impurities are mostly sulfate is purified with washing three times by redistilled water, and the purified fosetyl-Al could satisfy the demand of ion chromatography. The purified sample is further confirmed with iodimetry and ion chromatography, and its content is beyond 99.0%. The influences of common anions and the concentration of eluent on the separation of fosetyl-A1 are studied by using AS 14 and AS 9 analytical columns. The ion chromatography method to analyze fosetyl-Al isestablished with electronic conductivity detector, AS 9 column and Na2CO3 solution as eluent, and corresponding evaluate is also carried out. The results indicate that the accuracy（99. 6～100. 1%） and the precision with RSD of 0.31 % of the method are satisfying.