安脉颗粒提取工艺的正交优选

Study on Optimal Extract Technology of Anmai Granules by Orthogonal Test

目的对安脉颗粒提取工艺进行研究。方法采用正交设计试验法,以绿原酸及肉桂酸为指标,选取L9(34)正交表,考察乙醇浓度、乙醇用量、提取次数、提取时间等工艺参数对绿原酸及肉桂酸含量的影响。结果以饮片投料,加9倍量的70%乙醇,回流提取2次,每次1.0h为最佳工艺。结论该工艺稳定可靠,可用于生产。

Objective To optimize the extraction procedure for Anmal Granules. Methods With the content of Chlorogenic acid and Cinnamylic acid as indexes, orthogonal table L9（3^4） was used in the experiment of extracting in alcohol to study the effect of technological parameters （the concentration and dosage of alcohol, extraction times, the time of extraction） on the content of Chlorogenic acid and Cinnamylic acid. Results The optimum process is that 70% alcohol is used as extracting solution adding 9 times amount of solution, extracting 2 times, 1.0 hours for each time. Conclusion The extraction process is stable and suitable for industrial production.