珠海市125例登革热的临床表现和流行病学特征分析

Analysis of clinical manifestations and epidemiological features of 125 dengue fever cases in Zhuhai City

目的对2007年广东省珠海市登革热病例进行临床表现和流行病学特征分析。方法收集2007年8～10月间中山大学附属第五医院收治珠海市的125例登革热住院患者的流行病学和临床资料进行统计分析。结果发病年龄以20～39岁年龄组最多,发病高峰在9月上旬,主要爆发点1个,共有病例75例,占全部病例的60.0%。主要临床表现为发热(100.0%)、头痛(56.0%)、头晕(91.2%)、全身肌痛(63.2%)、疲乏(74.4%)、食欲减退(73.6%)、皮疹(68.8%)。实验室检查提示白细胞减少和血小板减少,分别占94.4%和93.6%,肝功能和心脏损害较明显。基因序列分析表明,此次流行主要为登革1型病毒。结论珠海市2007年流行的DF为登革1型病毒所致,病例符合典型DF的临床表现。经及时诊断和治疗,患者预后较好。

Objective To analyze the clinical and epidemiological characteristics of Dengue fever（DF） cases in Zhuhai City in 2007.Methods The clinical and epidemiological data of 125 DF cases between August and October in 2007 in The Fifth Affiliated Hospital of Sun Yat-sen University were analyzed.Results The infection rate in the age group of from 20 to 39 years old was the highest with a peak of infection in the first ten days in September and there was main infection cocus where 75 cases were reporteed accounted for 6.00%.The main clinical manifestations were fever（110%）,headache（56.8%）,dizziness（91.2%）,myalgia（63.2 %）,fatigue（74.4%）,lost of appetite（73.6%） and skin rash（68.8%）.Leukopenia and thrombocytopenia were observed in 94.4% and 93.6 % of the cases.Therehepatic lesions and cardiac impair were also noticed.The pathogenic virus genetically identified was Dengue virus type 1.Conclusion This epidemic of DF in Zhuhai in 2007 was caused by Dengue virus type 1 and typical DF manifestations are observed inmost of the patients.With early correct diagnosis and adequate treatment,the prognosis of DF patients is good.