深圳市龙岗区中学生乙型肝炎流行状况及防治对策

Survey of prevalant status of hepatitis B in middle school students of Longgang District and control measures

目的了解深圳市龙岗区中学生乙型肝炎病毒感染状况及影响因素,为制定有效的干预措施提供依据。方法采用酶联免疫吸附试验(ELISA法)检测HBV血清标志物(HBsAg、抗-HBs、HBeAg、抗-HBe、抗-HBc)和谷丙转氨酶(ALT)。结果共检测的1250名中学生,HBsAg阳性者66人,阳性率为5.28%;初中学生HBsAg的阳性率低于高中学生,差异有统计学意义(P<0.05);男生的感染率高于女生,差异有统计学意义(P<0.05);在HBsAg阳性的学生中,HBV-DNA阳性率为53.03%,HBeAg阳性率为60.61%。结论HBV感染与家族乙肝病史、输血及血制品的使用有关。中学生HBsAg阳性群体处于乙肝病毒复制活跃期,有较强的传染性。

Objective To understand infectious status of HBV in middle school students and the risk factors. Methods Fasting venous blood （5ml）was collected from middle school studends, HBV markers i.e. HBsAg, anti -HBs, anti -HBe, anti -HBc and glutamic pyruvic transaminase （ALT）were detected by ELISA method. Results There 84 students were positive for HBsAg with a positive rate of 5.28%, The positive rate in junior middle school studems was a little lower than the senior students, showing significantly statistical difference （ P 〈 0.05）, The infection rate in males was higher than that of the females, also showing siguificantly statistical difference. The positive rates for HBV - DNA and HBeAg were 53.03% and 60. 61% respectively among the students positive for HBsAg, Conclusion HBV infection is associated with famifial history of hepatitis B, blood transfusion and use of blood products.