55例老年糖尿病患者颈动脉内膜中层厚度的测定

Determination of carotid intima-media thickness in 55 elderly diabetes mellitus patients

目的探讨老年糖尿病患者颈动脉粥样硬化的相关因素。方法测定55例老年糖尿病患者的颈总动脉内膜中层厚度(IMT),同时测定糖化血红蛋白(HbA1c)、血脂。结果老年糖尿病患者的胆固醇(TC)和甘油三酯(TG)较非糖尿病患者增高〔TC(4.82±1.14)mmol/L与(4.37±0.93)mmol/L,TG(1.90±1.08)mmol/L与(1.50±1.03)mmol/L,P<0.05〕;合并高血压率为69.1%,高于非糖尿病患者(P<0.05)。糖尿病患者的IMT(1.24±0.35)mm较非糖尿病患者(1.06±0.19)mm显著性升高(P<0.05)。合并高血压的糖尿病患者的IMT(1.33±0.34)mm较无高血压者(1.03±0.28)mm明显增高,随年龄增加糖尿病患者的IMT逐步增加(P<0.05);HbA1c≤6.5%组的IMT较HbA1c>6.5%组低,但差异无统计学意义(P>0.05)。结论老年糖尿病患者存在血脂异常、合并高血压高的特点。这些因素、年龄和血糖控制差是动脉粥样硬化的危险因素,积极地纠正血脂和血压的异常及高血糖对于延缓动脉粥样硬化有重要的意义。

Objective To explore the relative factors of carotid atherosclerosis in elderly patients. Methods To determine intima-media thickness（IMT） and blood lipid, HbAlc in 55 elderly diabetes mellitus（DM） patients. Results TC,TG of DM were significatively iucreased compared with non-DM patients （TC（ 4.82 ± 1.14 ） mmol/L vs （ 4.37 ± 0.93 ） mmol/L, TG（ 1.90 ± 1.08） mmol/ L vs （1.50±1.03）mmol/L,P〈0. 05]. The incidence of hypertension in DM group （69. 1%） was markedly higher than that of non-DM group （P〈0.05）. IMT of DM were obviously thicker than non-DM patients（（1.24±0.35）mm vs （1.06±0.19）mm,P〈 0.05]. IMT in DM patients with hypertension（1.33± 0.34）mm were markedly higher compared with the patients without hypertension（1.03±0.28）mm,IMT were increased step by step with age（P〈0.05）. IMT in the group of HbAlc≤6.5% were reduced compared with the group of HbAlc〉6.5% （P〉0.05）. Conclusion The elderly DM patients have abnormal blood lipid and high incidence of hypertension. Besides these factors,age and blood glucose fell standard also speed progress of atherosclerosis. Thus,to actively control abnormal blood lipid, blood pressure and blood glucose is very important.