联合苦参素注射液治疗术后进展期胃癌的疗效分析

EFFECT OF OXYMATRINE INJECTION COMBINED WITH MITOMYCIN C AND TEGAFUR IN TREATMENT OF ADVANCED GASTRIC CANCER

[目的]探讨苦参素联合丝裂霉素和呋喃尿嘧啶(MF)治疗方案对进展期胃癌术后的治疗效果。[方法]将60例进展期胃癌术后患者随机分成对照组(24例)和治疗组(36例),对照组采用NF方案,治疗组在对照组的基础上加入苦参碱注射液。检测血清血管内皮生长因子(VEGF)水平,并对预后进行分析。[结果]进展期胃癌患者血清VEGF含量明显高于正常组(P﹤0.01),且与胃癌患者肿瘤的浸润深度、淋巴结转移、肿瘤大于4cm及TMN分期有关(均P﹤0.05)。术后14周时检测血清VEGF水平,观察组明显低于术前(P﹤0.05)而接近正常组水平,对照组仅降至术前水平。观察组、对照组中位生存时间分别为40和25个月。观察组的术后累计生存率高于对照组(P﹤0.05)。[结论]进展期胃癌患者术后采用MF方案联合苦参素治疗可明显降低血清VEGF含量,提高生存率。

[Objective] To evaluate the effects of oxymatrine combined with mitomycin C and tegafur （MF） on postoperative chemotherapy in advanced gastric cancer. [Methods] Sixty postoperative patients with advanced gastric cancer were rundomly divided into two groups, the control group （n = 24）, which received treatment with MF, and the therapy group, which treated with oxymatrine and MF. The serum VEGF levels in the control group and therapy group were detected preoperatively and postoperatively, meanwhile, the serum VEGF levels in 30 healthy persons were detected as comparison .Detected the serum VEGF levels and analyzed prognosis. [ Results] The levels of serum VEGF in advanced gastric cancer were higher than those in healthy persons （P 〈 0.01）, and were correlated with the depth of tumor invasion, lymph node metastasis, tumor size 〉 4cm and TNM stage （P 〈 0.05）. Fourteen weeks after operation, the levels of serum VEGF in therapy group decreased below those before operation and approached to normal range, while in the control group, the levels of serum VEGF decreased near those before operation only. The median survival time of patients in therapy group and control group was 40 and 25 months respectively. The survival rate of patients in therapy group was significantly higher than that in control （P 〈 0.05）. [Conclusion] The combined application of oxymatrine injection can decrease the concentration of serum VEGF and improve the survival rate in advanced gastric cancer patients.