糖皮质激素治疗特发性面神经麻痹发生医院感染的危险因素

RISK FACTORS OF NOSOCOMIAL INFECTION IN THE TREATMENT OF IDIOPATHIC FACIAL PALSY WITH GLUCOCORTICOIDS

[目的]评估应用糖皮质激素治疗特发性面神经麻痹(Bell’spalsy)发生医院感染的危险因素。[方法]回顾了我院收治的156例特发性面神经麻痹患者经糖皮质激素治疗发生医院感染的临床资料,对用药疗程及感染的发生进行相关性分析,对是否伴有糖尿病及患者年龄进行相对危险度分析。[结果]156例经糖皮质激素治疗的患者,有42例(26.9%)发生感染;糖皮质激素疗程4周发生医院感染较2周明显增高(t=7.035,P﹤0.01);合并糖尿病和老年特发性面神经麻痹患者发生感染的相对危险度分别为(χ=21.326,OR=11.614,P﹤0.01、χ=6.547,OR=5.874,22P﹤0.05)。[结论]特发性面神经麻痹患者应用糖皮质激素治疗发生医院感染与糖皮质激素疗程密切相关,合并糖尿病和老年患者是发生医院感染的危险因素。

[Objective] To evaluate risk factors of hospital infections in the treatment of idiopathic facial palsy with glucocorticoid. [Methods] Reviewed the clinical data on 156 cases of idiopathic facial palsy treated with glueocorticoid.The correlations between course of treatment with medication and the occurrence of infection were analyzed.Whether to have diabeles melhtus and patients＇ age were carried out the relative risk analysis. [ReSults] 42 cases in 156patients occurred infections during the treatment.The occurrence of infection in patients during treatment with glucoeorticoid for 4 weeks was significantly higher than for 2 weeks.The odds ratio of combining diabetes mellitus patients happened infection was 11.614 （95%CI, χ^2= 21.326, P 〈 0.01 ）, and that of old idiopathic facial palsy patients was 5.874 （95%CI,χ^2= 6.547, P 〈 0.05）. [Conclusion] The occurrence of hospital infections in the treatment of idiopathic facial palsy with glueocorticoid closely correlates with course of treatment with glueoeorticoid.Combining diabetes mellitus and senile patients is the risk factor of hospital infections.