重组γ-干扰素防止尖锐湿疣冷冻术后复发的疗效观察

Observation of the Effect of Rhinfr Pevented the Recurrence of Condyloma Acuminatum after the Freezed Treatment

７３例尖锐湿疣患者，随机分为３组，分别采取疣体冷冻后γ干扰素肌注或γ干扰素局部注射以及单纯疣体冷冻三种不同治疗方法，经１年随访，发现单纯疣体冷冻组２５例患者中９例复发，复发率为３６％，疣体冷冻加γ干扰素肌注组２４例中５例复发，复发率为２０８４％，疣体冷冻加γ干扰素局部注射组２４例中有３例复发，复发率为１２９２％。其结果经ｘ２检验显示：单纯疣体冷冻组与其余两组复发率有显著性差异（Ｐ＜００５），且其中与局部注射组差异尤为显著（Ｐ＜０００１）。认为，在尖锐湿疣疣体冷冻治疗后，局部运用γ干扰素可以增强机体细胞免疫功能，控制ＢＰＶ的亚临床感染，从而有效地减少了尖锐湿疣冷冻术后的复发。

73 patients of condyloma acuminatum divided 3 groups. The patients of lst group treated by rhINFγ intramuscular injection after condyloma frozen. The patients of 2nd group was treated by rhINFγ local injection after condyloma frozen. The 3rd group was treated by condyloma frozen. By follow up 6 moths after treatment, we found the rats of recurrence for lst group was 20.84%, 2nd group was 12.92% and 36% of 3rd group, the results examimation by X2 test appeared there was significantly difference of the effect of treatment between 3rd to 1st and 2nd group (p<005). We think local injected rhINFγ after condyloma froaen can reduced the rats of recurrence of the condyloma acuminatum frozen.