摘要
目的探讨转化生长因子β1在慢性鼻窦炎组织中的表达情况。方法采用逆转录-聚合酶链反应方法和免疫组化方法检测56例慢性鼻窦炎患者鼻窦黏膜组织中转化生长因子β1的mRNA和蛋白表达情况。结果转化生长因子β1在慢性鼻窦炎组织表达较下鼻甲黏膜组织增高。无论在mRNA水平还是蛋白水平的相对表达量均随着慢性鼻窦炎的病程发展显著增加,呈正相关。结论转化生长因子β1的表达增高,可能是促进慢性鼻窦炎发展和复发的一个重要因素。
Objective To investigate the expression of TGF-β1 gene in chronic rhinosinusitis tissues. Methods Reverse transcriptase polymerase chain reaction and immunohistochemistry methods were used to examine the expression of TGF-β1 gene in 56 chronic rhinosinusitis tissues. Results The mRNA and protein expressions of TGF-β1 gene in chronic rhinosinusitis tissues were increased than that in inferior turbinate mucosa tissues. The expression of TGF-β1 gene in chronic rhinosinusitis tissues was found positively related with progress of chronic rhinosinusitis. Conclusion The increased expression of TGF-β1 may be an important factor in promoting the progress and recrudescence of chronic rhinosinusitis.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2008年第3期284-286,共3页
Journal of Harbin Medical University
基金
黑龙江省留学归国人员科学技术专项资金项目(LC05C23)
哈尔滨医科大学博士启动基金(2006)
