眼部尿激酶与地塞米松离子导入治疗人工晶状体前膜的疗效观察

Observation on treatment for anterior fibrinous membrane after intraocular lens implantation with iontophoresis of urokinase and dexamethason in eyes

目的探讨眼部尿激酶和地塞米松离子导入治疗人工晶状体植入术后并发人工晶状体前膜的疗效。方法将人工晶状体植入术后并发人工晶状体前膜的患者64例,随机分为眼部尿激酶和地塞米松离子导入治疗组31例和非离子导入治疗组33例,观察2组人工晶状体前膜的吸收时间、治疗2周时的眼压变化。结果离子导入治疗组人工晶状体前膜平均吸收时间为(6.68±1.94)d,非离子导入治疗组人工晶状体前膜平均吸收时间为(8.33±2.19)d,2组比较差异有显著统计学意义(t=-3.20,P=0.00)。治疗2周时眼压水平:离子导入治疗组平均眼压为(1.99±0.44)kPa,非离子导入治疗组平均眼压为(2.36±0.35)kPa,2组比较差异有显著统计学意义(t=-3.77,P=0.00)。结论眼部尿激酶与地塞米松离子导入治疗人工晶状体前膜吸收快,安全、简便、有效,是一种新的给药途径,属无创性治疗。

Objective To explore effective method on treatment for anterior fibrinous membrane formation after intraocular lens implantation with iontophoresis of urokinase and dexamethason in eyes. Methods Sixty-four patients suffering the anterior fibrinous membrane formation after intraocular lens implantation were randomly divided into iontophoresis treated group （ 31 cases ） and non-iontophoresis treated group （ 33 cases）. The absorption time of anterior fibrinous membrane and the intraocular pressure changes after 2 weeks treatment were observed. Results In iontophoresis treated group, average absorption time of anterior fibrinous membrane was （6. 68 ± 1.94）days;In non-iontophoresis treated group, average absorption time of anterior fibrinous mem- brane was （ 8.33 ± 2.19 ） days. There were statistically significant differences of the average absorption time of anterior fibrinous membrane between the two groups （ t = - 3.20, P = 0.00 ）. The intraocular pressure level when treated at 2 weeks, average intraocular pressure in iontophoresis treated group was （ 1.99 ± 0. 44 ）kPa; average intraocular pressure in non-iontophoresis treated group was （ 2.36 ± 0.35 ） kPa. There were statistically significant differences of the intraocular pressure level when two weeks between the two groups（t = -3.77,P=0.00）. Conclusion The treatment for anterior fibrinous membrane formation after intraocular lens implantation with iontophoresis of urokinase and dexamethason in eyes is rapid-absorb- ing, safe, simple, effective, and a new administration route which belong to non-invasive treatment.