原发性高血压患者尿微量白蛋白与高敏C反应蛋白及脉压

High-sensitivity C-reactive Protein,Pulse Pressure and Microalbuminuria in Patients with Essential Hypertension

目的探讨原发性高血压(EH)患者尿微量白蛋白与高敏 C 反应蛋白(hsCRP)及脉压(PP)的关系。方法 EH 患者60例根据尿微量白蛋白(MAU)含量分为高血压尿微量白蛋白组(MAU 组,n=30)含量和高血压尿正常白蛋白组(NMAU 组,n=30)及健康对照组30例。测定各组 MAU、hscRP 及 PP 等,并进行比较。结果MAU 组的 hsCRP 及 PP 均高于 NMAU 组及对照组(P 均<0.05),EH 患者 hsCRP(r=0.42,P<0.05)及 PP(r=0.62,P<0.05)与 MAU 均呈正相关(P<0.05)。偏相关分析矫正年龄、收缩压(SBP)、舒张压(DBP)、血糖等因素后 hsCRP(r=0.26,P<0.05),PP(r=0.32,P<0.05)仍然保持与尿白蛋白排泄量(UAE)相关。结论合并MAU 的 EH 患者体内 hsCRP 增高,脉压增大,EH 患者肾损害与 hsCRP 及 PP 水平有关。

Objective To investigate the relationship between high-sensitivity C-reactive protein（hsCRP）, pulse pressure（PP） and microalbuminuria（MAU） in patients with essential hypertension. Methods Consecutive 60 patients with essential hypertension were classified based on the MAU level： patients with MAU（n=30） and the group of patients with normoalbuminuria（NMAU, n=30） with 30 healthy subjects as control. MAU, hsCRP, PP were determined. Results The level of hsCRP and pulse pressure in MAU group were higher than those in NMAU patients and healthy subjects （P〈0.05）; Level of MAU was positively related with concentration of hsCRP （r=0.42,P〈0.05） and PP（r=0. 62, P〈0.05） in patients with EH （P〈0.05）. After adjusting for age, SBP, DBP and blood sugar, hsCRP（ r=0.26, P〈0.05）and PP（ r= 0.32, P〈0.05）remain positively related with UAE. Conclusion Renal damage is related with the levels of hsCRP and pulse pressure in essential hypertension.