幽门螺杆菌感染对冠心病患者血脂和血浆高敏C反应蛋白的影响

The Effect of Helicobacter Pylori Infection on Plasma Lipid and High Sensitive C Reactive Protein Levels in Patients with Coronary Heart Disease

目的探讨冠心病患者幽门螺杆菌感染对血脂和血浆高敏C反应蛋白的影响,并探讨其可能的发病机制。方法对确诊的159例冠心病患者且近期无感染性疾病及慢性炎症性疾病,采用呼气试验来检测是否感染幽门螺杆菌,根据呼气试验将冠心病患者分为感染阴性组、轻度感染组和重度感染组,同时测定血浆高敏C反应蛋白、血尿酸、血纤维蛋白原和血脂水平。结果与感染阴性组患者比,幽门螺杆菌感染阳性组患者总胆固醇、低密度脂蛋白及高敏C反应蛋白水平明显升高,甘油三酯水平降低(P<0.05);重度感染组高敏C反应蛋白水平明显高于轻度感染组(P<0.05)。结论幽门螺杆菌感染可能通过影响脂质代谢,从而加重血管壁的炎症反应;在冠心病患者中,幽门螺杆菌感染阳性患者可能有更高的心血管事件发生。

Aim To investigate the effect of Helicobacter pylori （Hp） infection on plasma lipicl and high sensitive C reactive protein （hs-CRP） levels in patients with coronary heart disease （CHD）. Methods 159 CHD patients were recruited for this study. And plasma fibrinegen, plasma lipid, plasma urine acid and hs-CRP were examined in all subjects. Expiratory test were executed in all subjects. All subjects were divided into negative infection group, slight infection group and serious in- fection group. Results In patients with Hp infection, plasma hs-CRP, total cholesterol （TC） and low density lipoprotein cholesterol （LDLC） were significantly higher, but triglyceride （TG） level was lower, compared with negative infection group （P〈0.05）; Plasma hs-CRP was significantly higher in serious infection group than in slight infection group （P〈0.05）. Conclusion Hp infection may increase vascular inflammatory reaction through lipid metabolic disturbance. There maybe have higher cardiovascular events rates in CHD patients with Hp infection.