前列腺癌的流行病学特征及晚期一线内分泌治疗分析

Epidemiology of prostate cancer from three centers and analysis of the first-line hormonal therapy for the advanced disease

目的分析北京、上海、广州的三个中心前列腺癌的流行病学特征，初步反映中国发达地区的前列腺癌现状。对晚期前列腺癌患者内分泌治疗相关资料进行分析，寻找内分泌治疗效果以及生存预后的预测因子。方法收集三个中心525例前列腺癌患者的临资料，进行流行病学分析。并对其中272例资料完整的晚期前列腺癌患者的内分泌治疗效果以及生存预后进行分析。结果68．0％的患者确诊时已属于晚期，80．2％的患者以内分泌治疗为主要治疗手段。Gleason分值、有无骨转移和血清前列腺特异性抗原最低点是晚期前列腺癌疾病进展的独立预后因子。结论绝大多数患者在确诊时已经为疾病晚期，内分泌治疗是主要治疗方法。Gleason分值、有无骨转移和PSA最低点是晚期前列腺癌疾病进展的独立预后因子。

Objectives To analyze the epidemiology information of prostate cancer from three centers of Bejing, Shanghai, Guangzhou, and to reflect the current situation of prostate cancer in China, and to analyze the information of 272 patients with advanced prostate cancer who received hormonal therapy to find the prognostic factors of hormone therapy. Methods Collect the information of 525 patients with prostate cancer from three centers. Two hundred and seventy-two cases of advanced prostate cancer with full information were selected from the 525 cases to analyze the prognostic factors of hormone therapy. Results Three hundred and fifty-seven cases （68.0%） had advanced disease at diagnosis and 80. 2% patients received hormone therapy as the main therapy, Prognostic analysis indicated that Gleason score, bone metastasis and prostate specific antigen nadir were independent prognostic factors of progression-free survival time. Conclusions In this report, most patients are advanced prostate cancer at diagnose, and hormonal therapy is the main therapy. Gleason score, bone metastasis, prostate specific antigen nadir are independent prognostic factors of advanced prostate cancer after hormone therapy.