中国居民代谢综合征的家庭聚集性分析

Analysis on family aggregation of metabolic syndrome in Chinese population

目的探讨中国居民代谢综合征(MS)的患病是否具有家庭聚集性。方法资料来源于2002年中国居民营养与健康状况调查,MS家庭聚集性的定性分析采用二项分布和β-二项分布拟合优度的χ2检验,家庭聚集性的大小估计采用组内相关系数表示,并采用logistic回归以及偏相关分析MS及其构成指标在配偶、子女、父母及兄弟姐妹之间的相关性。结果用二项分布和β-二项分布进行拟合优度的χ2检验,发现MS的患病情况存在家庭聚集现象。组内相关系数为0.0576,聚集程度属于微弱。在调整户主年龄、性别和6类地区后,户主的MS构成指标(包括收缩压、舒张压、体质指数、腰围、高密度脂蛋白、总胆固醇、总甘油三脂、空腹血糖)与子女、配偶、父母亲及兄弟姐妹的MS构成指标均有相关性。结论中国居民代谢综合征的患病呈现一定的家庭聚集性。

Objective To explore whether there was family aggregation of MS in Chinese population. Methods The data were from Chinese nutrition and health survey in the year 2002. The quality analysis on family aggregation of MS was used by chi-square test for fitness according to binomial distribution and beta binomial distribution, with aggregation degree evaluated by intra-class correlation coefficient. The correlations of MS and its component between wife and husband, son and daughter, mother and father, and brother and sister were analyzed by logistic regression and partial correlation. Results Family aggregation of MS was found by chi-square test for fitness according to binomial distribution and beta binomial distribution. Intra-class correlation coefficient was 0. 057 6, which was weak by Landis and Koch＇s definition. Adjusted by age, gender and area, MS components of householder were associated significantly with those of offspring, spouse, parent, and sibling including SBP, DBP, BMI, and waist circumference, HDLC, TC, TG and FBG. Conclusions The family aggregation exists among Chinese population.