食管癌行为生活方式危险因素的病例对照研究

Case-control study on the risk factors in behavior and life style of esophageal carcinoma

目的分析行为生活方式对食管癌的影响。方法采用1∶3和1∶4不等比配比的病例对照研究方法,用自行设计的行为生活方式问卷对来自太原市典型抽样的社区健康人群199例和山西省肿瘤医院住院食管癌患者60例进行调查。数据录入采用Epi Data3.0,统计分析采用SPSS11.5统计软件进行χ2检验、条件配对logistic回归分析。结果单因素配对logistic回归分析显示,文化程度、职业、吸烟习惯、吸烟开始年龄、喜吃热烫饮食、吃饭速度、喜喝清汤、茶水过夜与食管癌相关,多因素配对logistic回归分析显示吸烟习惯、喜吃热烫饮食、吃饭速度快、常喝过夜茶水、喜喝清汤是食管癌的危险因素,OR（95%CI）值分别为2.787（1.239-6.267）、2.131（1.017-4.469）、2.079（1.019-4.241）、1.084（1.030-1.141）、2.704（1.759-4.156）。结论吸烟习惯、热烫饮食、吃饭速度快、茶水过夜、喜喝清汤均是食管癌的主要行为生活方式危险因素。

Objective To analyse the risk factors in behavior and llfe style of esophageal carcinoma. Methods The study was carried out using a ease-control method with 1 ： 3 and 1 ： 4 and all subjects were investigated with self-deslgned questionnaire about behaviors and lifestyle. The data entering was carried out with Epi Data 3.0 and statistic analysis by SPSS with x^2-test and palr-loglstlc regression analysis. Results Single variable pair-logistic regression showed that education, occupation, history of smoking, smoking-start age, preference for hot food, eating fast, and light soup, and drinking overnight tea had correlation with esophageal carcinoma. Analysis of multiple variables pair-logistic regression showed that history of smoking, preference for hot food, light soup, and overnight tea, as well as eating fast were the main behavior risk factors of esophageal carcinoma. Their OR （95% CI） were 2.787 （1.239- 6,267）, 2. 131 （1.017- 4. 469）, 2. 079 （1.019- 4. 241）, 1.084 （1.030- 1.141）, 2. 704 （1.759- 4.156） respectively. Conclusions History of smoking, preference for hot sood, light soup, and overnight tea, as well as eating fast are the main behavior risk factors of esophageal carcinoma.