系统性红斑狼疮心脏损害临床研究

Some clinical studies on systemic lupus erythematosus patients with cardiac involvement

目的探讨系统性红斑狼疮(SLE)心脏损害的临床特征,并分析年龄、性别、病程及实验室指标与SLE心脏损害的相关性。方法回顾性分析安徽医科大学第一附属医院1060例SLE的临床资料。结果①SLE可累及心脏各部分,其中以心电图ST-T缺血性改变多见。②SLE心脏损害多属无症状型,与年龄和病程无关。③抗心磷脂抗体与心脏瓣膜损害关系较密切。结论SLE并发心脏损害时常无明显临床症状,故对SLE病人需要常规作超声心动图、心电图和抗磷脂抗体检查,有助于提高心脏病变的检出率,积极防治。

Objective To explore clinical features of systemic lupus erythematosus （SLE）with cardiac involvement and relationship between cardiac abnomalities and some parameters and laboratory findings, Methods The clinical data in 1 060 SLE patients were reviewed. Results （1）Every part of the heart could be involved. ST-T ischemic changes in ECG was the most frequent among the cardiac manifestations. （2）Most patients with cardiac lesions were asymptomatic. Cardiac involvement in SLE was not associated with the course of disease and age. （3）There was relatively close relationship between anticardiollpin antibody （ACA） and valve involvement. Conclusions The SLE patients with cardiac impairment often have no typical symptom. Ultrasonic cardiogram （UCG）, electrocardiogram （ECG） and ACA test are helpful in increasing the diagnosis and active prevention and cure.