白细胞介素2与狂犬疫苗联合免疫小鼠的抗体动态观察

Interleukin2 as an adjuvent to increase the antibodies level of inactivated rabies virus vaccine

组织培养制备的狂犬病毒灭活疫苗与重组白细胞介素２同时免疫ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠，检测不同时间的鼠血清中抗狂犬病毒ＩｇＧ抗体和中和抗体效价。结果显示，在白细胞介素２的作用下，抗体产生的时间提前，抗体效价提高（Ｐ＜０．０１），ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠比较，前者的抗体效价更高（Ｐ＜０．０１）。说明白细胞介素２可以提高小鼠的体液免疫反应。

We were interested in determining whether the interleukin2 (IL2) could be an adjuvent to increase the immune response of mouse to inactivated rabies virus vaccine.BALB/c mice and Swiss mice were divided equally into two groups respectively.They were immunized by the inactivated rabies virus vaccine with IL2 or without IL2.The results showed that the antivirus IgGantibodies and virusneutralizing antibodies had appeared 5 days earlier for the group with IL2 than the one without IL2.The antibody titer had raised much higher for the group with IL2 than another one.