低体重儿脐血单胺类物质含量变化的临床意义

Changes of Concentrations of Umbilical Blood Monoamines in Low Birth Weight Infant and Their Clinical Significance

目的：探讨低体重儿（ＬＢＷ）体内单胺类物质的含量变化及其临床意义。方法：用荧光分光光度法测定了１８例ＬＢＷ产前、产后脐血去甲肾上腺素（ＮＥ）、多巴胺（ＤＡ）、５－羟色胺（５－ＨＴ）和５－羟吲哚乙酸（５－ＨＩＡＡ）的含量，并与２０例正常体重儿（ＮＢＷ）进行比较。结果：无论产前或产后，ＬＢＷ各项单胺类物质（尤其ＮＥ和ＤＡ）的含量均显著低于ＮＢＷ（Ｐ＜０．０５～０．０１）；产后与产前相比，各项单胺类物质的含量均有所升高，其中ＮＢＷ的ＮＥ升高差异有显著意义（Ｐ＜０．０５）。结论：ＬＢＷ单胺类物质含量过低，可能是导致ＬＢＷ死亡率高及智力和身体发育障碍的原因之一。

Objective: To investigate the changes of concentrations of umbilical blood monoamines in low birth weight (LBW) infants and their clinical significance. Methods: By fluorescence spectrophotometry, the concentrations of umbilical plasma norepinephrine (NE), dopamine (DA), 5 hydroxytryptamine (5 HT) and 5 hydroxyindoleacetic acid (5 HIAA) in 18 LBW before and after delivery were measured and compared with 20 normal birth weight (NBW) infants. Results: The concentration of all monoamines, especially of the 2 catecholamines, i.e. NE and DA, were markedly lower in LBW than that in NBW ( P <0.05￣0.01), regardless of prepartus or postpartus; the concentrations of all monoamines in postpartal umbilical plasma in both of LBW and NBW were higher than those in prepartal, and the increase of NE in NBW showed significant difference ( P <0.05). Conclusions: The decrease of all monoamines, especially of catecholamines in LBW could be one of the reasons causing the increase of mortality and the decrease of mental and physical development in LBW.