新型杀虫剂甲磺虫腙的合成与杀虫活性

Synthesis and Bioactivity of Novel Insecticide ZJ0967

以对氯苯甲酰氯、苯甲醚、甲基磺酰氯、水合肼、丁酮等为原料合成了新型杀虫剂甲磺虫腙（试验号：ZJ0967）,其化学名称为甲磺酸-4-[（4-氯代苯基）-（丁酮腙叉）-甲基]苯酯,其结构经^1H NMR、MS和元素分析确认。室内生测结果表明,甲磺虫腙对小菜蛾Plutella xylostella、甜菜夜蛾Spodoptera exigua,特别是对粘虫Mythimna sepatara、斜纹夜蛾Prodenia litura表现出良好的杀虫活性。进一步毒力测定表明,甲磺虫腙对斜纹夜蛾的LC50值为8.45（7.69～9.62）mg/L,其杀虫活性与虫酰肼相当,但低于氟啶脲。田间试验结果表明,70%甲磺虫腙WG在有效成分为210～420g/hm^2时,对斜纹夜蛾7d的防效可达88.6%～93.9%,未观察到对作物产生药害。

4-[（sec-Butylidene-hydrazono）-（4-chlorophenyl）-methyl]-phenyl methane sulfonate（ZJ0967） as a novel insecticide was synthesized by using 4-chlorobenzoyl chloride,methoxybenzene,methane sulfonyl chloride,hydrazine hydrate,and 2-butanone as starting materials.The structure of ZJ0967 was confirmd by ^1H NMR,MS and elemental analysis.Its insecticidal activity was evaluated.ZJ0967 exhibited higher insecticidal activity against Mythimna sepatara and Prodenia litura,followed by Plutella xylostella and Spodoptera exigua.The LC50 value against P.litura was 8.45（7.69～9.62）mg/L.The activity of ZJ0967 against P.litura was almost equivalent to that of tebufenozide,but lower than that of chlorfluazuron.Field trials showed that the control effect of ZJ0967（70%WG） against Prodenia litura was 88.6%～93.9% after seven days at the rate of 210～420 g a.i./hm^2.No crop injury was observed at the dosage of the tests.