新生儿缺氧缺血性脑病早期干预的研究

STUDY OF EARLY MEDICAL INTERVENTION ON NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY

①目的观察早期干预对防治缺氧缺血性脑病（ＨＩＥ）病儿脑功能障碍的效果。②方法将５７例ＨＩＥ病儿随机分为干预组（２９例）和对照组（２８例）。干预组自新生儿期开始接受早期干预。两组均于１．５岁、２．０岁按双盲法进行Ｂａｙｌｅｙ婴幼儿智能发育量表测试。③结果干预组在１．５岁时Ｂａｙｌｅｙ测试精神发育指数（ＭＤＩ）较对照组高１３．２分，两组比较差异均有极显著意义（ｔ＝３．２９，Ｐ＜０．０１），运动发育指数（ＰＤＩ）高８．７分，两组比较差异有显著性（ｔ＝２．３２，Ｐ＜０．０５）；２岁时ＭＤＩ较对照组高１４．２分，ＰＤＩ高９．３分，两组比较差异均有极显著性（ｔ＝３．２７，２．７９，Ｐ均＜０．０１）。④结论早期干预对防治ＨＩＥ病儿脑功能障碍有显著效果。

Objective To study the effect of early medical intervention on neonates with hypoxic ischemic encephalopathy(HIE). Methods Fifty seven neonates with hypoxic ischemic encephalopathy were randomly divided into early intervention group(29 cases) and control group(28 cases). Early intervention commenced at neonatal stage. Bayley scales was applied to determine infant development. Results The average scores of MDI and PDI in early intervention group were 13.2 and 8.7 higher than those of the control group at the age of 1.5 years( t=3.29,2.32,P<0.01,0.05) and 14.2 and 9.3 higher than the control group at the age of 2 years( t=3.27,2.79,P<0 01) . Conclusion The results demonstrate that early medical intervention can promote intellectual development of the neonates with HIE and prevent mental retardation.