放射性核素肝胆动态显像对胆囊切除术后患者胆汁动力学研究

Research of Bile Dynamics in Patients After Cholecystectomy by Hepatobiliary Scintigraphy

目的:应用肝胆动态显像测定胆囊切除术后患者及正常对照组的胆汁动力学变化参数,从而为诊断Oddi′s括约肌(SO)功能障碍(SOD)提供依据。方法:正常对照组12例,胆囊切除术后患者18例。所有受试者行脂餐介入肝胆动态显像,之后数据处理得出胆汁排泌参数。结果:与正常对照组比较,胆囊切除术后组十二指肠显影时间(DAT)及胆总管通过时间(HDTT)差异有显著;而肝高峰摄取时间(Tmax)、半排时间(T1/2)、胆总管高峰摄取时间(Tmax)及半排时间(T1/2)差异无显著性;脂餐介入后胆总管半排时间明显缩短。结论:胆囊切除术后患者的平均胆汁排空速度较术前速度加快,且胆汁动力学参数在不同患者间仅存在微小的变异,这些参数将为SO功能障碍患者的检出提供依据。

Objective：To examine the dynamics of bile in patients after cholecystectomy and normal controls, get the parameters of normal changes of bile emptying in patients after cholecystectomy and to help diagnosing SOD. Methods ：Patients：12 normal controls and 18 patients after cholecystectomy. All patients were measured by fatty meal intervented hepatobiliary scintigraphy. The parameters of bile emptying were calculated and compared. Results：DAT and HDTT in patients after cholecystectomy decreased and Tmax in liver and common bile duct.T1/2 in liver and common bile duct showed no difference in comparison with normal control group. Conclusions ：After cholecystectomy, the bile emptying parameters show faster bile emptying and only minor patient-to-patient variations.