乙酰水杨酸对实验性动脉粥样硬化形成过程中脂代谢的影响

The Effect of Low_dose ASA on Lipid Metabolism in Blood and Tissues of Atherosclerotic Rabbits and the Clinical Role which ASA Plays

雄性家兔３４只，体重１５～２５ｋｇ，随机分为３组喂养：正常组（１０只）饲以基础饲料，模型组（１２只）加饲胆固醇１５ｇ·ｄ－１／只，预防组（１２只）加饲胆固醇１５ｇ·ｄ－１／只及乙酰水杨酸ＡＳＡ７５饲ｍｇｄ１／ｋｇ，持续３月。结果显示，与同期模型组相比，预防组血浆ＴＣ、ＬＤＬ＿Ｃ、ＡｐｏＢ水平明显下降，ＨＤＬ＿Ｃ／ＴＣ升高，主动脉组织Ｃｈ、ＡｐｏＢ及肝脏组织Ｃｈ含量减少，主动脉粥样硬化程度减轻，肝脏脂肪性变亦轻但有部分白细胞浸润。血浆ＴＧ在２组间差异无显著性，ＨＤＬ及其亚类的绝对水平差异不恒定。认为，小剂量ＡＳＡ能够降低致ＡＳ脂质因子的水平，升高ＨＤＬ占总脂的比例，并据此发挥预防ＡＳ形成的作用。ＡＳＡ的肝脏损伤应引起重视。

?4 male New Zealand rabbits ,weighing 1.5～2.5 kg, were randomly divided into 3 groups:10 rabbits in a normal group were fed only with basic diet; 12 in a model group ,each with additional cholesterol (Ch) 1.5 mg/d and 12 in a precention group ,each with additional Ch 1.5 mg/d and acetylsalicylic acid (ASA) 7.5 mg .kg1/d for 3 months .The results showed that compared to model group ,low_dose ASA in the prevention group had significant effects of lowering plasma total Ch (TC),low density lipoprotein Ch and apolipoprotein B (ApoB) levels ,raising the ratio of high density lipoprotein Ch (HDL_C)/TC,preventing the accumulation of Ch and ApoB in the aorta and Ch in the liver tissues accompanied by the reduction of the extent of aortic atherosclerosis (AS) and hepatic fatty degeneration, with inflammatory cells infiltrating in some portal areas of the liver. No significant difference of plasma triglyceride level and no constant difference of the absolute content of HDL and its subtypes were found between the two groups. It is suggested that low-dose ASA can prevent the formation of AS in such ways as lowering the level of atherogenic lipids and increasing the ratio of HDLC/TC. The hepatic lesion effect of ASA should be pay attention to.