摘要
将卡介菌多糖核酸（ＢＣＧ＿ＰＳＮ）及肿瘤坏死因子（ＴＮＦ＿α）用于荷肉瘤（Ｓ１８０）小鼠的治疗。结果证明，ＢＣＧ＿ＰＳＮ（０５ｍｇ／ｍｌ）及ＴＮＦ＿α（１０００Ｕ／ｍｌ）均能显著抑制Ｓ１８０实体瘤的生长，抑瘤率分别为５８１０％和３６２５％，抑瘤率与荷瘤鼠脾细胞的ＩＬ＿２诱生水平呈正的直线相关。ＢＣＧ＿ＰＳＮ还能显著延长荷Ｓ１８０腹水瘤鼠的存活期，生命延长率达３１５％。ＴＮＦ可能由于它的毒副作用而使其抑瘤效果低于ＢＣＧ＿ＰＳＮ，且与后者无协同作用。
Polysaccharides nucleic acid fraction of BCG (BCG_PSN) and tumor necrosis factor alpha (TNF_α) were used to treat bearing S 180 sarcoma mice. It has been comfirmed that both BCG_PSN and TNF_α can inhibit the growth of S 180 solid sarcoma significantly, the inhibitory rates were 58.10% and 36.25% respectively. The level of interleukin 2 of splenocytes appeared to be in positive linear correlation with the inhibitory rates. BCG_PSN can also markedly prolong the living period of bearing S 180 ascites sarcoma mice. TNF had no sinergistic antitumor activity in combination with BCG_PSN and the efficiency of inhibiting tumor growth of TNF was lower than that of BCG_PSN due to its side_effect, whereas BCG_PSN did not appear to produce any side_effect in this study.
