急性冠状动脉综合征合并抑郁症的治疗体会

目的观察抗抑郁治疗对急性冠状动脉综合征(ACS)并抑郁症患者心血管事件的影响。方法将93例ACS伴抑郁症的患者进行心理评估,随机分为对照组、治疗组。对照组给予单纯常规心脏病药物治疗,治疗组在常规心脏病药物治疗基础上给予抗抑郁药物—氟西汀(fluoxetion)治疗,比较两组近期心血管事件的发生率。结果治疗组心肌缺血明显改善,心绞痛复发率及急性心肌梗死发生比率与对照组比较,差异有统计学意义(P<0.05)。结论对于ACS合并抑郁症的患者加用抗抑郁药物治疗能明显降低不稳定型心绞痛发作,减少心血管事件的发生率。

Objective To investigate primarily the influence of antidepressive therapy on cardiovascular events in the acute coronary syndrome （ ACS ） patients with depression. Methods 93 ACS patients with depression were divided equally into control group and fluoxetion group. The control groiap were given conventional treatment for ACS and the fluoxetion group were given both conventional treatment and Fluoxetion （50 mg ,qd） . The incidence of short-term cardiovascular events of between two groups were compared. Results The incidence rates of angina and acute myocardial infarction in fluoxetion group were significantly decreased as compared with the control group （ P 〈 0.05）. Conclusion Antidepression can significantly improve the short-term prognosis in ACS patients with depression.