摘要
采用大剂量氨甲喋呤（ＨＤ＿ＭＴＸ３０００ｍｇ·ｍ－２／次）治疗２９例小儿急性淋巴细胞白血病（ＡＬＬ）８５例次。治疗前及治疗期间给予大量补液及碱化尿液；治疗开始后６ｈ和３６ｈ分别给于四氢叶酸钙（ＣＦ）口腔滴入和静脉注射。结果发生粘膜损伤４例（４７％），显著低于单纯ＣＦ静注组（Ｐ＜００５）。治疗前后肌酐、尿素氮及外周血白细胞无明显变化。提示大量补液、碱化尿液可预防ＭＴＸ的肾毒性，并能显著降低粘膜损伤的发生率。
cases of acute lymphoblastic leukemia (ALL) treated with 85 infusions of high dosage Methotrexate (HD_MTX) were studied. The MTX 3 000 mg·m -2 /24 h. Citrovorum Factor (CF) was administered oral and intravenous at 6 and 36 hours after MTX, respectively. It was necessary to intake quantites of water and maintain a condition of alkalinuria through the period of MTX. Renal function returned to normal range after the administration of these methods. The rate of catarrh was 4.7%( P <0.05). It was shown that oral administration and intravenous route of CF reduce the rate of catarrh.
关键词
白血病
淋巴细胞性
氨甲喋呤
药物疗法
急性
MeSH leukemia, lymphoblastic, acute
methotrexate/TU
methotrexate/AE
clinic study
