1Donn R,Ellison S,Lamb R,et al.Genetic loci contribu-ting to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthri-tis[].Arthritis and Rheumatism.2008
2Vivarelli M,D‘Urbano LE,Insalaco A,et al.Macrophage migrationinhibitory factor(MIF)and oligoarticular ju-venile idiopathic arthritis(o-JIA):association of MIF pro-moter polymorphisms with response tointra-articular glu-cocorticoids[].Clinical and Experimental Rheumatology.2007
3Stock CJ,Ogilvie EM,Samuel J M,et al.Comprehensive association study of genetic variants in the IL-1gene fam-ily in systemic juvenile idiopathic arthritis[].Genes Im-mun.2008
4Wei CM,Lee J H,Wang LC,et al.Frequency and pheno-typic analysis of CD4+CD25+regulatory T cells in chil-dren withjuvenileidiopathic arthritis[].J Microbiol Im-munol Infect.2008
5Nistala K,Moncrieffe H,Newton KR.Interleukin-17-pro-ducing Tcells are enriched in the joints of children with arthritis,but have a reciprocal relationship to regulatory Tcell numbers[].Arthritis and Rheumatism.2008
6Ravelli A,Felici E,Magni-Manzoni S,et al.Patients with antinuclear antibody-positive juvenile idiopathic arthritis constitute a homogeneous subgroup irrespective of the course of joint disease[].Arthritis and Rheumatism.2005
7Massa M,Passalia M,Manzoni SM,et al.Differential recognition of heat-shock protein dnaJ-derived epitopes by effector and Treg cells leads to modulation of inflam-mation in juvenile idiopathic arthritis[].Arthritis and Rheumatism.2007
8Kamphuis S,,Kuis W,de Jager W,et al.Tolerogenic im-mune responses to novel T-cell epitopes from heat-shock protein60in juvenile idiopathic arthritis[].The Lancet.2005
9Moroldo MB,Chaudhari M,Shear E,et al.Juvenile rheu-matoid arthritis affected sibpairs:extent of clinical pheno-type concordance[].Arthritis and Rheumatism.2004
10Flat B,Smerdel A,Johnston V,et al.The influence of pa-tient characteristics,disease variables,and HLAalleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis[].Arthritis and Rheumatism.2002
5Bokarewa M,Bokarew D,Hultgren O. Leptin consumption in the inflamed joints of patients with rheum atoid arthritis[J].Annals of the Rheumatic Diseases,2003,(10):952-956.doi:10.1136/ard.62.10.952.
6MacRae VE,Farquharson C,Ahmed SF. The pathophysiology of growth plate in juvenile idiopathic arthritis[J].Rheumatology,2006,(09):11-19.
7Adams A,Lehman TJ. Update on the pathogenesisand treatmentof systemic onset juvenile rheumatoid atthritis[J].Rheumatology,2005,(05):612-616.
8Beurler BA. The role of tumor necrosis factor in health and disease[J].Rheumatology,1999,(08):16-21.
9National Health and Medical Research Council. Clinical guideline for the diagnosis and management of juvenile idiopathic arthritis. 2009: 43P.
10AGREE Next Steps Consortium. The AGREE II Instrument, 2011. Available at: http://www.agreetrust.org.
