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柬埔寨农村地区HIV合并结核病的流行情况

The epidemiology of HIV-associated tuberculosis in rural Cambodia
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摘要 地点:柬埔寨Banteay Meanchey省。目的:世界卫生组织建议在结核病和艾滋病双重感染流行的国家,对所有的结核病人进行艾滋病病毒(HIV)检测,并对所有HIV感染者和病人进行结核病筛查。本文探求在东南亚国家是否有证据支持这一建议的可行性。设计:本研究为横断面调查,对2003年10月—2005年2月新诊断的艾滋病病毒感染者或结核病人进行回顾性的队列研究,以明确HIV感染和患结核病的危险因素,并确定抗结核治疗过程中的死亡情况。结果:574例结核病人中发现HIV感染者216例(38%),450例艾滋病病毒感染者和病人中诊断结核病病人124例(24%)。无任何组别的病人处于HIV感染或患结核病的低风险。180例艾滋病合并结核病且有抗结核治疗转归记录,其中49例(27%)死亡,而未感染HIV的357例结核病人中17例(5%)死亡(相对危险度5.2,95%可信区间为3.1—8.7)。感染HIV的涂阴肺结核病人的死亡率常常低于涂阳肺结核病人(相对危险度0.39,95%可信区间0.16—0.93)。结论:无任何组别的病人处于HIV感染或患结核病的低风险,感染HIV的结核病人的死亡率高。这些数据证明:在东南亚国家,应实施世界卫生组织的全球TB/HIV双重感染建议。有必要采取紧急干预措施,以降低艾滋病合并结核病病人的死亡率。
出处 《国际结核病与肺部疾病杂志》 2008年第1期29-34,共6页 The International Journal of Tuberculosis and Lung Disease
基金 the United States Agency for Interna tional Development for funding both the TB-HIV project in Banteay Meanchey and this evaluation WHO Cambodia Family Health International (FHI)and the Japan Internationl Cooperation Agency(JICA)who sponsor the other three TB-HYV pilot projects started in 2003 and who each provided valuable information
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参考文献10

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