双氢克尿噻治疗盐敏感高血压的疗效观察

Observation of dihydrochloride on salt-sensitivity hypertension

目的:观察双氢克尿噻治疗盐敏感高血压的疗效。方法:125例盐敏感高血压患者,按年龄分为青年组、中年组和老年组;按血压水平分为轻度、中度和重度高血压。给予双氢克尿塞12.5 mg口服,2次/d,疗程6周,观察治疗前后各指标的变化。结果:轻中度高血压患者治疗后收缩压(SBP)、舒张压(DBP)显著下降(P<0.01),重度高血压则下降不明显(P>0.05);青年及中年组血压下降明显(P<0.01),老年组下降不明显(P>0.05)。无血糖(Bs)、肌酐(Cr)、尿素氮(BUN)、血钾(K)、血清钠(Na)、血脂三项及血尿酸(UA)等代谢异常。结论:双氢克尿噻能够有效治疗中青年的轻中度盐敏感高血压。

Objective： To observe the effect of dihydrochloride in patients salt-sensitivity hypertension.Method： 125 patients with salt-sensitivity hypertension were divided into three groups： youth group, middle-age group and old-age groups; According to the degree of blood pressure, the 125 patients were divided into three group： mild, moderate and severe. They were treated with dihydrochloride 12.5 mg twice a day for six weeks. Result： After treatment, patients with mild and moderate hypertension showed significant lowering of diastolic blood pressure and systolic blood pressure（ P 〈 0.01 ）, while in patients with severe hypertension, the lowing was not significant（ P 〉 0.05 ）. In youth and middle-age group, diastolic blood pressure and systolic blood pressure decreased（ P 〈 0.01 ）, but old- age group were not significant（ P 〉 0.05 ）. The levels of blood potassium, urea nitrogen, sugar, natrium, creatinine, lipids and uric acid were within normal limits. Conclusion： Dihydrochloride can effectively control youth and middleage patients of mild and moderate salt-sensitivity hypertension.