期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

胰岛素样生长因子结合蛋白-4的基因结构及表达调控研究

Progress of the Genomic Organization,Expression and Regulation of Insulin-like Growth Factor Binding Protein-4 Gene
下载PDF
导出
摘要 IGFBP-4是分子最小的IGFBP,它以糖基化和非糖基化两种形式存在于所有的生物流体中。表达IGFBP-4的细胞和组织极其广泛,并且其表达调控机制也因细胞类型不同而有所差异。本文主要是对IGFBP-4的基因组成、基因表达与调控、IGF-BP-4蛋白结构与功能的关系进行了综述。 IGFBP--4 is the smallest of the six high-affinity IGFBPs. It exists in both non-glycosylated and glycosylated forms in all biological fluids.In this review, we summarize the present knowledge of the genomic organization of the IGFBP--4 gene, structure-function relationships of IGFBP--4,and IGFBP--4 expression and its regulation.
作者 王桂武 杨福合 孙红梅 鲍加荣
机构地区 吉林农业科技学院 中国农业科学院特产研究所
出处 《特产研究》 2008年第2期73-75,78,共4页 Special Wild Economic Animal and Plant Research
基金 国家科技支撑计划项目(2006BAD6B06)
关键词 胰岛素样生长因子结合蛋白-4 基因结构 表达调控 IGFBP--4 G-enomic organization Expression regulation
分类号 Q78 [生物学—分子生物学]
  • 相关文献

参考文献22

  • 1Allander SV, Bajalica S, Larsson C, Luthman H, Powell DR, Stem I, Weber G, Zazzi H & Ehrenborg E Structure and chromosomal localization of human insulin-like growth factor-binding protein genes. [J].Growth Regulation, 1993,3: 3-5.
  • 2G-ao L, Ling N & Shimasaki S Structure of the rat insulin-like growth factor binding protein-4 gene.:Biochemical and Biophysical Research Communications, 1993,190:1053- 1059.
  • 3Zazzi H, Nikoshkov A, Hall K & Luthman H Structure and transcription regulation of the human insulin-like growth factor binding protein 4 gene (IGFBP4).[J].Genomics,1998, 49:401-410.
  • 4Dai B, Widen SG, Mifflin R & Singh P Cloning of the functional promoter for human insulin-like growth factor binding protein-4 gene: endogenous regulation. [J].Endocrinology, 1997, 138:332-343.
  • 5Glantschnig H, Varga F, Luegmayr E & Klaushofer K Characterization of the mouse insulin-like growth factor binding protein 4 gene regulatory region and expression studies. [J]. DNA and Cell Biology, 1998, 17:51-60.
  • 6Houck CM, Rinehart FP & Schmid CW A ubiquitous family of repeated DNA sequences in the human genome. [I]. Journal of Molecular Biology, 1979, 132:289-306.
  • 7Batzcr MA & Dcininger PL Alu repeats and human genornic diversity.[J]. Nature Reviews. Genetics, 2002, 3:370-379.
  • 8Rajaram S, Baylink DJ & Mohan S Insulin-like growth factorbinding proteins in scnan and other biological fluids: regulation and functions. [J].Endocrine Reviews, 1997, 18: 801-831.
  • 9Shimasaki S, Uchiyama F, Shimonaka M & Ling N Molecular cloning of the cDNAs encoding a novel insulin-like growth factorbinding protein from rat and human.[J]. Molecular Endocrinology, 1990, 4:1451-1458.
  • 10van Kleffens M, Groffen CA, Dits NF, Lindenbergh-Kortleve DJ, Schuller AG, Bradshaw SL, Pintar JE, Zwartlaoff EC, Drop SL & van Neck JW Generation of antisera to mouse insulin-like growth factor binding proteins (IGFBP) -1 to -6: comparison of IGFBP protein and messenger ribonucleic acid localization in the mouse embryo.[J].Endoerinology, 1999,140:5944-5952.
特产研究
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部