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丙酮二羧酸及其衍生物的合成研究 被引量：2

Synthesis of 1,3-Acetone Dicarboxylic Acid and Its Derivatives
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摘要 丙酮二羧酸及其衍生物是重要的医药中间体,以无水柠檬酸为原料经氧化脱羧得到丙酮二羧酸,再经酯化和硼氢化钾还原反应制备得到3-羟基戊二酸二乙酯,总收率94%,纯度98.5%。 1,3-Acetone dicarboxylic acid and its derivatives were important intermediates for drug synthesis. In this paper diethyl 3-oxopentanedioate was synthesized using anhydrous citric acid as starting material, then reacted with ethanol to produce diethyl 3-oxopentanedioate. The ester product was reduced by KBH4 to afford diethyl 3- hydroxypentanedioate, the total yield was 94% and the purity was 98.5%.
作者 唐新军 徐建兵 臧阳陵
机构地区 湖南化工职业技术学院 湖南化工研究院国家农药创制工程技术研究中心
出处 《精细化工中间体》 CAS 2008年第3期33-35,共3页 Fine Chemical Intermediates
关键词 无水柠檬酸 氯磺酸 丙酮二羧酸 还原 合成 anhydrous citric acid chlorosulfonic acid 1,3-acetone dicarboxylic acid reduction synthesis
分类号 O625.56 [理学—有机化学]
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参考文献14

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共引文献5

同被引文献30

  • 1王强,潘红娟,袁哲东.雷尼酸锶的合成[J].中国医药工业杂志,2007,38(2):76-77. 被引量：6
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精细化工中间体
2008年 第3期

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