阿托伐他汀对老年高血压患者动脉弹性和踝臂指数的影响

Effect of atorvastatin on the arterial elasticity and ankle-brachial index in geriatric hypertensives

目的探讨阿托伐他汀对老年高血压患者动脉弹性和踝臂指数(ABI)的短期影响。方法选择87例老年高血压患者,随机分为对照组42例和阿托伐他汀组(治疗组)45例,治疗3个月。观察治疗前后,肱动脉脉压、脉搏波传导速度(PWV)、大、小动脉弹性指数(C1和C2)和ABI的变化。结果对照组治疗前后,各指标均无显著改变。治疗组治疗后与治疗前比较,脉压降低(4.09±8.58)mmHg(1mmHg=0.133kPa),PWV下降(1.6±3.15)m/s,C2增高(0.42±0.97)ml/mmHg×100,ABI增高(0.08±0.16),差异有统计学意义(P<0.05,P<0.01)。结论阿托伐他汀可改善高血压患者C2和PWV、缩小脉压,同时对外周血管疾病也有改善作用。

Objectives To observe the effect of atorvastatin on the arterial elasticity and anklebrachial index（ABI） in old patients with essential hypertension. Methods Eighty-seven patients with essential hypertension regularly taking antihypertension drugs were divided into control group （n =42） and atorvastatin group （n =45）and treated for 3 months. Brachial pulse pressure （PP） ,automatic pulse wave velocity （PWV）, elastic indexes of large and small arteries（C1 and C2）, and ABI were measured before and after treatment. Results No change of all measurements in control group was found after treatment. In atorvastatin group, however, PP decreased by （4. 09±8.58） mm Hg, PWV decreased by （1.6±3.15） m/s,C2 increased by （0.42±0.97） ml/ mm Hg×100 （P 〈0.05） ,ABI increased by （0.08±0.16, P 〈0.01）. Conclusions Atorvastatin can reduce pulse pressure through improvement of C2 and PWV, and simultaneously improve peripheral vascular disease.