老年脑卒中患者高同型半胱氨酸血症与颈动脉狭窄的关系

The relationship between hyperhomocysteinemia and carotid stenosis in old stroke patients

目的研究老年脑卒中患者高同型半胱氨酸血症(HHcy)与颈动脉狭窄的关系。方法选择>60岁的颈动脉系统缺血性脑卒中患者126例行全脑血管造影术,根据造影结果分为轻度狭窄组(52例)、中度狭窄组(46例)和重度狭窄组(28例),另选健康体检者50例为正常对照组。应用微粒子酶联免疫分析法测定同型半胱氨酸(Hcy)。结果颈动脉各狭窄组血清Hcy水平显著高于正常对照组(P<0.01);重度狭窄组血清Hcy水平显著高于中度狭窄组及轻度狭窄组(P<0.01),中度狭窄组显著高于轻度狭窄组(P<0.01)。结论HHcy是动脉粥样硬化的重要危险因素,与颈动脉狭窄的严重程度相关。

Objective To study the relationship between hyperhomocysteinemia and carotid stenosis in old stroke patients. Methods 126 patients（above 60 years old） with carotid ischemic stroke were examined by digital subtraction angiography to detect carotid stenosis. The patients were divided into three groups, the slight stenosis group, the moderate stenosis group and the severe stenos norma norma s group. The serum homocysteine（Hcy）levels in different groups were compared with the group. Results The Hcy level was significantly higher in the stenosis groups than in the group （P 〈0.01） ,significantly higher in the severe stenosis group than in the slight moderate stenosis groups （P 〈0.01）, and significantly higher in the moderate stenosis group than in the slight stenosis group （P 〈0.01）. Conclusion Hyperhomocysteinemia may be an important risk factor for atherosclerosis, and it is highly correlated with the severity of the carotid stenosis.