刍议靶向治疗药物在乳腺癌治疗中的疗效和安全性
Evaluation of Efficacy and Safety for Targeted Agents in the Treatment of Breast Cancer
摘要
乳腺癌是常见的恶性肿瘤之一,随着世界人口结构的老龄化和生活方式的西化.其发病率始终居高不下^[1]。但近30年来,由于化疗药物的层出不穷,化学治疗的广泛应用.临床试验的深入开展.乳腺癌的死亡率显著下降^[2]。然而,常规化疗的最大弊端就在于其影响面较广,多牵连无辜,因为它不仅针对肿瘤细胞,
出处
《循证医学》
CSCD
2008年第3期129-131,共3页
The Journal of Evidence-Based Medicine
关键词
乳腺肿瘤
靶向治疗
疗效
安全性
breast neoplasms
target therapy
efficacy
safety
参考文献11
-
1Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007 [ J ]. CA Cancer J Clin, 2007,57 ( 1 ) : 43-66.
-
2Early Breat Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials[J]. Lancet, 2005,365(9472) : 1687-1717.
-
3Brackstone M, Townson JL, Chambers AF, et al. Tumour dormancy in breast cancer: An update[J]. Breast Cancer Res, 2007,9(3) :208.
-
4Geyer CE, Forster J, Lindquist D, el al. Lapatinib plus Capecitabine for HER2-positive advanced breast cancer [J]. N Engl J Med, 2006,355(26) : 2733-2743.
-
5Miller K, Wang M, Gralow J, et al. Paclitaxel plus Bevacizumab versus Paclitaxel alone for metastatic breast cancer[ J ]. N Engl J ned, 2007,357 (26) : 2666-2676
-
6Romond EH, Perez EA, Bryant J, et al. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer[J]. N Engl J Med, 2005,353(16):1673-1684.
-
7Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer[J]. N Engl J Med, 2005,353(16) : 1659-1672.
-
8Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for breast cancer[J ]. N Engl J Med, 2006, 354(8) :809-820.
-
9Slamon D, Eiermann W, Robert N, et al. BCIRG 006: 2nd interim analysis phase Ⅲ randomized trial comparing Doxorubicin and Cyclophosphamide followed by Docetaxel (AC→T) with Doxorubicin and Cyclophosphamide followed by Docetaxel and Trastuzumab (AC→TH) with Docetaxel, Carboplatin and Trastuzumab (TCH) in Her2neu positive early breast cancer patients. Paper presented at the 29th San Antonio Breast Cancer Symposium [C]. Gonzalez Convention Center, San Antonio, Texas, USA, 2006.
-
10Smith IE, Walsh G, Skene A, et al. A phase Ⅱ placebocontrolled trial of neoadjuvant Anastrozole alone or with Gefitinib in early breast cancer [J]. J Clin Oncol, 2007,25 (25) :3816-3822.
-
1余传定.刍议暗示在肿瘤诊治中的作用[J].抗癌,2002(4):30-30.
-
2岳光成,张艳锋,苏文中.刍议腔镜食管癌根治术在食管癌治疗中的临床应用效果[J].中国医药指南,2015,13(21):208-209. 被引量:2
-
3常敏毅.大蒜抗肿瘤刍议[J].抗癌,2003(1):21-21.
-
4章文华,吴令英.宫颈癌综合治疗刍议[J].抗癌,2003(3):12-13.
-
5郁宝铭.直肠癌保肛手术刍议[J].抗癌,2003(4):8-9.
-
6管忠震.临床肿瘤学进展及我国肿瘤防治工作刍议[J].中国肿瘤,1992,1(7):18-19.
-
7蔡建华.PET/CT在诊断口腔颌面部肿瘤颈淋巴结转移中的价值刍议[J].医药与保健,2014,0(3):157-157.
-
8詹文华.胃癌围术期辅助治疗利弊刍议[J].消化肿瘤杂志(电子版),2016,8(3):139-141.
-
9蒋敏杰.刍议双侧平衡去骨瓣减压术应用于重型闭合性颅脑损伤的临床疗效[J].中外医疗,2014,33(12):53-54. 被引量:3
-
10黎鳌.对烧伤防治研究的刍议[J].中华创伤杂志,1990,6(4):193-197. 被引量:1