期刊文献+

刍议靶向治疗药物在乳腺癌治疗中的疗效和安全性

Evaluation of Efficacy and Safety for Targeted Agents in the Treatment of Breast Cancer
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摘要 乳腺癌是常见的恶性肿瘤之一,随着世界人口结构的老龄化和生活方式的西化.其发病率始终居高不下^[1]。但近30年来,由于化疗药物的层出不穷,化学治疗的广泛应用.临床试验的深入开展.乳腺癌的死亡率显著下降^[2]。然而,常规化疗的最大弊端就在于其影响面较广,多牵连无辜,因为它不仅针对肿瘤细胞,
出处 《循证医学》 CSCD 2008年第3期129-131,共3页 The Journal of Evidence-Based Medicine
关键词 乳腺肿瘤 靶向治疗 疗效 安全性 breast neoplasms target therapy efficacy safety
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参考文献11

  • 1Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2007 [ J ]. CA Cancer J Clin, 2007,57 ( 1 ) : 43-66.
  • 2Early Breat Cancer Trialists' Collaborative Group (EBCTCG). Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials[J]. Lancet, 2005,365(9472) : 1687-1717.
  • 3Brackstone M, Townson JL, Chambers AF, et al. Tumour dormancy in breast cancer: An update[J]. Breast Cancer Res, 2007,9(3) :208.
  • 4Geyer CE, Forster J, Lindquist D, el al. Lapatinib plus Capecitabine for HER2-positive advanced breast cancer [J]. N Engl J Med, 2006,355(26) : 2733-2743.
  • 5Miller K, Wang M, Gralow J, et al. Paclitaxel plus Bevacizumab versus Paclitaxel alone for metastatic breast cancer[ J ]. N Engl J ned, 2007,357 (26) : 2666-2676
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  • 7Piccart-Gebhart MJ, Procter M, Leyland-Jones B, et al. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer[J]. N Engl J Med, 2005,353(16) : 1659-1672.
  • 8Joensuu H, Kellokumpu-Lehtinen PL, Bono P, et al. Adjuvant Docetaxel or Vinorelbine with or without Trastuzumab for breast cancer[J ]. N Engl J Med, 2006, 354(8) :809-820.
  • 9Slamon D, Eiermann W, Robert N, et al. BCIRG 006: 2nd interim analysis phase Ⅲ randomized trial comparing Doxorubicin and Cyclophosphamide followed by Docetaxel (AC→T) with Doxorubicin and Cyclophosphamide followed by Docetaxel and Trastuzumab (AC→TH) with Docetaxel, Carboplatin and Trastuzumab (TCH) in Her2neu positive early breast cancer patients. Paper presented at the 29th San Antonio Breast Cancer Symposium [C]. Gonzalez Convention Center, San Antonio, Texas, USA, 2006.
  • 10Smith IE, Walsh G, Skene A, et al. A phase Ⅱ placebocontrolled trial of neoadjuvant Anastrozole alone or with Gefitinib in early breast cancer [J]. J Clin Oncol, 2007,25 (25) :3816-3822.

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